Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function.

Chen, Panpan; Zhang, Qianbin; Zhang, Huizhen; Gao, Yue; Zhou, Yanying; Chen, Yixin; Guan, Lihuan; Jiao, Tingying; Zhao, Yingyuan; Huang, Min; Bi, Huichang

Chen, Panpan; Zhang, Qianbin; Zhang, Huizhen; Gao, Yue; Zhou, Yanying; Chen, Yixin; Guan, Lihuan; Jiao, Tingying; Zhao, Yingyuan; Huang, Min; Bi, Huichang.

Afiliación

Chen P; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Zhang Q; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Zhang H; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Gao Y; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Zhou Y; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Chen Y; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Guan L; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Jiao T; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Zhao Y; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Huang M; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Bi H; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.

J Cell Physiol ; 236(2): 958-970, 2021 02.

Article en En | MEDLINE | ID: mdl-32632982

Asunto(s)

Carnitina O-Palmitoiltransferasa/genética; Senescencia Celular/genética; Fibroblastos/fisiología; Metabolismo de los Lípidos/genética; Mitocondrias/genética; Adenosina Trifosfato/genética; Línea Celular; Proliferación Celular/genética; Regulación hacia Abajo/genética; Humanos; Potencial de la Membrana Mitocondrial/genética; ARN Mensajero/genética; Regulación hacia Arriba/genética; beta-Galactosidasa/genética

Palabras clave

MRC-5 fibroblasts; carnitine palmitoyltransferase 1C (CPT1C); cellular senescence; lipidomics; mitochondrial function

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carnitina O-Palmitoiltransferasa / Senescencia Celular / Metabolismo de los Lípidos / Fibroblastos / Mitocondrias Límite: Humans Idioma: En Revista: J Cell Physiol Año: 2021 Tipo del documento: Article País de afiliación: China

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