Antimycin A shows selective antiproliferation to oral cancer cells by oxidative stress-mediated apoptosis and DNA damage.

Yu, Tzu-Jung; Hsieh, Che-Yu; Tang, Jen-Yang; Lin, Li-Ching; Huang, Hurng-Wern; Wang, Hui-Ru; Yeh, Yun-Chiao; Chuang, Ya-Ting; Ou-Yang, Fu; Chang, Hsueh-Wei

Yu, Tzu-Jung; Hsieh, Che-Yu; Tang, Jen-Yang; Lin, Li-Ching; Huang, Hurng-Wern; Wang, Hui-Ru; Yeh, Yun-Chiao; Chuang, Ya-Ting; Ou-Yang, Fu; Chang, Hsueh-Wei.

Afiliación

Yu TJ; Department of Biomedical Science and Environmental Biology, PhD program in Life Science, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.
Hsieh CY; Department of Biomedical Science and Environmental Biology, PhD program in Life Science, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.
Tang JY; Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Lin LC; Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Huang HW; Department of Radiation Oncology, Chi-Mei Foundation Medical Center, Tainan, Taiwan.
Wang HR; School of Medicine, Taipei Medical University, Taipei, Taiwan.
Yeh YC; Chung Hwa University of Medical Technology, Tainan, Taiwan.
Chuang YT; Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Ou-Yang F; Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Chang HW; Department of Biomedical Science and Environmental Biology, PhD program in Life Science, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.

Environ Toxicol ; 35(11): 1212-1224, 2020 Nov.

Article en En | MEDLINE | ID: mdl-32662599

Asunto(s)

Antimicina A/farmacología; Antineoplásicos/farmacología; Proliferación Celular/efectos de los fármacos; Neoplasias de la Boca; Acetilcisteína/farmacología; Antimicina A/metabolismo; Apoptosis/efectos de los fármacos; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Daño del ADN/efectos de los fármacos; Humanos; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Mitocondrias/metabolismo; Oxidación-Reducción; Estrés Oxidativo/efectos de los fármacos; Extractos Vegetales/farmacología; Poli(ADP-Ribosa) Polimerasas/metabolismo; Especies Reactivas de Oxígeno/metabolismo

Palabras clave

antibiotics; drug repurposing; oral cancer; oxidative stress; selective antiproliferation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Proliferación Celular / Antimicina A / Antineoplásicos Límite: Humans Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Taiwán

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