Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives.

Corrie, Lu Wenchi; Stokes, Clare; Wilkerson, Jenny L; Carroll, F Ivy; McMahon, Lance R; Papke, Roger L

Corrie, Lu Wenchi; Stokes, Clare; Wilkerson, Jenny L; Carroll, F Ivy; McMahon, Lance R; Papke, Roger L.

Afiliación

Corrie LW; Department of Pharmacology and Therapeutics, College of Medicine (L.W.C., C.S., R.L.P.) and Department of Pharmacodynamics, College of Pharmacy, (J.L.W., L.R.M.), University of Florida, Gainesville, Florida; and Center for Drug Discovery, Research Triangle Institute, Durham, North Carolina (F.I.C.).
Stokes C; Department of Pharmacology and Therapeutics, College of Medicine (L.W.C., C.S., R.L.P.) and Department of Pharmacodynamics, College of Pharmacy, (J.L.W., L.R.M.), University of Florida, Gainesville, Florida; and Center for Drug Discovery, Research Triangle Institute, Durham, North Carolina (F.I.C.).
Wilkerson JL; Department of Pharmacology and Therapeutics, College of Medicine (L.W.C., C.S., R.L.P.) and Department of Pharmacodynamics, College of Pharmacy, (J.L.W., L.R.M.), University of Florida, Gainesville, Florida; and Center for Drug Discovery, Research Triangle Institute, Durham, North Carolina (F.I.C.).
Carroll FI; Department of Pharmacology and Therapeutics, College of Medicine (L.W.C., C.S., R.L.P.) and Department of Pharmacodynamics, College of Pharmacy, (J.L.W., L.R.M.), University of Florida, Gainesville, Florida; and Center for Drug Discovery, Research Triangle Institute, Durham, North Carolina (F.I.C.).
McMahon LR; Department of Pharmacology and Therapeutics, College of Medicine (L.W.C., C.S., R.L.P.) and Department of Pharmacodynamics, College of Pharmacy, (J.L.W., L.R.M.), University of Florida, Gainesville, Florida; and Center for Drug Discovery, Research Triangle Institute, Durham, North Carolina (F.I.C.).
Papke RL; Department of Pharmacology and Therapeutics, College of Medicine (L.W.C., C.S., R.L.P.) and Department of Pharmacodynamics, College of Pharmacy, (J.L.W., L.R.M.), University of Florida, Gainesville, Florida; and Center for Drug Discovery, Research Triangle Institute, Durham, North Carolina (F.I.C.)

Mol Pharmacol ; 98(4): 328-342, 2020 10.

Article en En | MEDLINE | ID: mdl-32690626

Asunto(s)

Compuestos Bicíclicos Heterocíclicos con Puentes/farmacología; Agonistas Nicotínicos/farmacología; Subunidades de Proteína/metabolismo; Piridinas/química; Receptores Nicotínicos/metabolismo; Animales; Animales Modificados Genéticamente; Encéfalo/metabolismo; Compuestos Bicíclicos Heterocíclicos con Puentes/química; Humanos; Estructura Molecular; Complejos Multiproteicos/metabolismo; Agonistas Nicotínicos/química; Subunidades de Proteína/genética; Receptores Nicotínicos/genética; Tropanos/química; Tropanos/farmacología; Xenopus/genética

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Receptores Nicotínicos / Agonistas Nicotínicos / Compuestos Bicíclicos Heterocíclicos con Puentes / Subunidades de Proteína Límite: Animals / Humans Idioma: En Revista: Mol Pharmacol Año: 2020 Tipo del documento: Article

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