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Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts.
Silventoinen, Karri; Jelenkovic, Aline; Sund, Reijo; Latvala, Antti; Honda, Chika; Inui, Fujio; Tomizawa, Rie; Watanabe, Mikio; Sakai, Norio; Rebato, Esther; Busjahn, Andreas; Tyler, Jessica; Hopper, John L; Ordoñana, Juan R; Sánchez-Romera, Juan F; Colodro-Conde, Lucia; Calais-Ferreira, Lucas; Oliveira, Vinicius C; Ferreira, Paulo H; Medda, Emanuela; Nisticò, Lorenza; Toccaceli, Virgilia; Derom, Catherine A; Vlietinck, Robert F; Loos, Ruth J F; Siribaddana, Sisira H; Hotopf, Matthew; Sumathipala, Athula; Rijsdijk, Fruhling; Duncan, Glen E; Buchwald, Dedra; Tynelius, Per; Rasmussen, Finn; Tan, Qihua; Zhang, Dongfeng; Pang, Zengchang; Magnusson, Patrik K E; Pedersen, Nancy L; Dahl Aslan, Anna K; Hwang, Amie E; Mack, Thomas M; Krueger, Robert F; McGue, Matt; Pahlen, Shandell; Brandt, Ingunn; Nilsen, Thomas S; Harris, Jennifer R; Martin, Nicholas G; Medland, Sarah E; Montgomery, Grant W.
Afiliación
  • Silventoinen K; Department of Social Research, Faculty of Social Sciences, University of Helsinki, P.O. Box 18, 00014, Helsinki, Finland. karri.silventoinen@helsinki.fi.
  • Jelenkovic A; Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan. karri.silventoinen@helsinki.fi.
  • Sund R; Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country, Leioa, Spain.
  • Latvala A; Department of Public Health, University of Helsinki, Helsinki, Finland.
  • Honda C; Department of Social Research, Faculty of Social Sciences, University of Helsinki, P.O. Box 18, 00014, Helsinki, Finland.
  • Inui F; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
  • Tomizawa R; Department of Social Research, Faculty of Social Sciences, University of Helsinki, P.O. Box 18, 00014, Helsinki, Finland.
  • Watanabe M; Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Sakai N; Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Rebato E; Faculty of Health Science, Kio University, Nara, Japan.
  • Busjahn A; Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Tyler J; Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Hopper JL; Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Ordoñana JR; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
  • Sánchez-Romera JF; HealthTwiSt GmbH, Berlin, Germany.
  • Colodro-Conde L; Twins Research Australia, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia.
  • Calais-Ferreira L; Twins Research Australia, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia.
  • Oliveira VC; Department of Epidemiology, School of Public Health, Seoul National University, Seoul, Korea.
  • Ferreira PH; Department of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.
  • Medda E; IMIB-Arrixaca, Murcia, Spain.
  • Nisticò L; Department of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.
  • Toccaceli V; IMIB-Arrixaca, Murcia, Spain.
  • Derom CA; Department of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.
  • Vlietinck RF; Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Loos RJF; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
  • Siribaddana SH; Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil.
  • Hotopf M; Musculoskeletal Health Research Group, Faculty of Health Sciences, The University of Sydney, Sydney, Australia.
  • Sumathipala A; Istituto Superiore di Sanità - Centre for Behavioural Sciences and Mental Health, Rome, Italy.
  • Rijsdijk F; Istituto Superiore di Sanità - Centre for Behavioural Sciences and Mental Health, Rome, Italy.
  • Duncan GE; Istituto Superiore di Sanità - Centre for Behavioural Sciences and Mental Health, Rome, Italy.
  • Buchwald D; Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
  • Tynelius P; Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium.
  • Rasmussen F; Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
  • Tan Q; The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine At Mount Sinai, New York, NY, USA.
  • Zhang D; Institute of Research and Development, Battaramulla, Sri Lanka.
  • Pang Z; Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka Saliyapura, Anuradhapura, Sri Lanka.
  • Magnusson PKE; Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK.
  • Pedersen NL; South London and Maudsley NHS Foundation Trust, London, UK.
  • Dahl Aslan AK; Institute of Research and Development, Battaramulla, Sri Lanka.
  • Hwang AE; Research Institute for Primary Care and Health Sciences, School for Primary Care Research (SPCR), Faculty of Health, Keele University, Staffordshire, UK.
  • Mack TM; Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Krueger RF; Washington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA.
  • McGue M; Washington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA.
  • Pahlen S; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
  • Brandt I; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
  • Nilsen TS; Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
  • Harris JR; Department of Public Health, Qingdao University Medical College, Qingdao, China.
  • Martin NG; Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
  • Medland SE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Montgomery GW; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Sci Rep ; 10(1): 12681, 2020 07 29.
Article en En | MEDLINE | ID: mdl-32728164
ABSTRACT
We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural-geographic regions. A classical twin design was applied to pooled data from 28 cohorts representing 16 countries and including 193,518 twins with information on educational attainment at 25 years of age or older. Genetic factors explained the major part of individual differences in educational attainment (heritability a2 = 0.43; 0.41-0.44), but also environmental variation shared by co-twins was substantial (c2 = 0.31; 0.30-0.33). The proportions of educational variation explained by genetic and shared environmental factors did not differ between Europe, North America and Australia, and East Asia. When restricted to twins 30 years or older to confirm finalized education, the heritability was higher in the older cohorts born in 1900-1949 (a2 = 0.44; 0.41-0.46) than in the later cohorts born in 1950-1989 (a2 = 0.38; 0.36-0.40), with a corresponding lower influence of common environmental factors (c2 = 0.31; 0.29-0.33 and c2 = 0.34; 0.32-0.36, respectively). In conclusion, both genetic and environmental factors shared by co-twins have an important influence on individual differences in educational attainment. The effect of genetic factors on educational attainment has decreased from the cohorts born before to those born after the 1950s.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Gemelos Dicigóticos / Gemelos Monocigóticos / Carácter Cuantitativo Heredable Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: America do norte / Asia / Europa / Oceania Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Finlandia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Gemelos Dicigóticos / Gemelos Monocigóticos / Carácter Cuantitativo Heredable Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: America do norte / Asia / Europa / Oceania Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Finlandia