A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool.
J Exp Med
; 217(10)2020 10 05.
Article
en En
| MEDLINE
| ID: mdl-32728699
ABSTRACT
An increasing body of evidence emphasizes the role of tissue-resident memory T cells (TRM) in the defense against recurring pathogens and malignant neoplasms. However, little is known with regard to the origin of these cells and their kinship to other CD8+ T cell compartments. To address this issue, we followed the antigen-specific progeny of individual naive CD8+ T cells to the T effector (TEFF), T circulating memory (TCIRCM), and TRM pools by lineage-tracing and single-cell transcriptome analysis. We demonstrate that a subset of T cell clones possesses a heightened capacity to form TRM, and that enriched expression of TRM-fate-associated genes is already apparent in the circulating TEFF offspring of such clones. In addition, we demonstrate that the capacity to generate TRM is permanently imprinted at the clonal level, before skin entry. Collectively, these data provide compelling evidence for early stage TRM fate decisions and the existence of committed TRM precursor cells in the circulatory TEFF compartment.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T CD8-positivos
/
Células Precursoras de Linfocitos T
/
Memoria Inmunológica
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
2020
Tipo del documento:
Article
País de afiliación:
Países Bajos