Osteocalcin, ovarian senescence, and brain health.
Front Neuroendocrinol
; 59: 100861, 2020 10.
Article
en En
| MEDLINE
| ID: mdl-32781196
ABSTRACT
Menopause, an inevitable event in a woman's life, significantly increases risk of bone resorption and diseases such as Alzheimer's, vascular dementia, cardiac arrest, and stroke. The sole role of bones, as traditionally regarded, is to provide structural support for skeletal muscles and allow for ambulation, however this concept is becoming quickly outdated. New literature has emerged that suggests the bone cell-derived hormone osteocalcin (OCN) plays a pivotal role in cognition. OCN levels are correlated with bone mass density and bone turnover, and thus are strongly influenced by the changes associated with menopause. The goal of the current review is to discuss potential gaps in our knowledge of OCN and cognition, discrepancies in methods of OCN quantification, and therapies to enhance circulating OCN. A discussion on implementing exercise or low frequency vibration interventions at the menopausal transition to reduce risk and severity of neurological diseases and associated cognitive decline is included.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ovario
/
Encéfalo
/
Menopausia
/
Osteocalcina
/
Cognición
/
Disfunción Cognitiva
Límite:
Female
/
Humans
Idioma:
En
Revista:
Front Neuroendocrinol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos