Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development.

Ledo, Jose Henrique; Zhang, Ran; Mesin, Luka; Mourão-Sá, Diego; Azevedo, Estefania P; Troyanskaya, Olga G; Bustos, Victor; Greengard, Paul

Ledo, Jose Henrique; Zhang, Ran; Mesin, Luka; Mourão-Sá, Diego; Azevedo, Estefania P; Troyanskaya, Olga G; Bustos, Victor; Greengard, Paul.

Afiliación

Ledo JH; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, United States of America.
Zhang R; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.
Mesin L; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, New York, United States of America.
Mourão-Sá D; Laboratory of Immune Cell Epigenetics and Signaling, The Rockefeller University, New York, New York, United States of America.
Azevedo EP; Laboratory of Molecular Genetics, The Rockefeller University, New York, New York, United States of America.
Troyanskaya OG; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.
Bustos V; Flatiron Institute, Simons Foundation, New York, New York, United States of America.
Greengard P; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, United States of America.

PLoS One ; 15(8): e0237773, 2020.

Article en En | MEDLINE | ID: mdl-32822378

Asunto(s)

Redes Reguladoras de Genes; Microglía/fisiología; Presenilina-1/metabolismo; Células Madre/metabolismo; Animales; Encéfalo/embriología; Encéfalo/metabolismo; Femenino; Masculino; Ratones Endogámicos C57BL; Fosforilación; Presenilina-1/genética; Células Madre/citología; Transcriptoma

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre / Microglía / Presenilina-1 / Redes Reguladoras de Genes Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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