Your browser doesn't support javascript.
loading
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.
Ng, Susanna S; De Labastida Rivera, Fabian; Yan, Juming; Corvino, Dillon; Das, Indrajit; Zhang, Ping; Kuns, Rachel; Chauhan, Shashi Bhushan; Hou, Jiajie; Li, Xian-Yang; Frame, Teija C M; McEnroe, Benjamin A; Moore, Eilish; Na, Jinrui; Engel, Jessica A; Soon, Megan S F; Singh, Bhawana; Kueh, Andrew J; Herold, Marco J; Montes de Oca, Marcela; Singh, Siddharth Sankar; Bunn, Patrick T; Aguilera, Amy Roman; Casey, Mika; Braun, Matthias; Ghazanfari, Nazanin; Wani, Shivangi; Wang, Yulin; Amante, Fiona H; Edwards, Chelsea L; Haque, Ashraful; Dougall, William C; Singh, Om Prakash; Baxter, Alan G; Teng, Michele W L; Loukas, Alex; Daly, Norelle L; Cloonan, Nicole; Degli-Esposti, Mariapia A; Uzonna, Jude; Heath, William R; Bald, Tobias; Tey, Siok-Keen; Nakamura, Kyohei; Hill, Geoffrey R; Kumar, Rajiv; Sundar, Shyam; Smyth, Mark J; Engwerda, Christian R.
Afiliación
  • Ng SS; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • De Labastida Rivera F; School of Environment and Science, Griffith University, Nathan, Queensland, Australia.
  • Yan J; Institute of Experimental Oncology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Corvino D; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Das I; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Zhang P; School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
  • Kuns R; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Chauhan SB; School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
  • Hou J; Institute of Experimental Oncology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Li XY; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Frame TCM; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • McEnroe BA; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Moore E; Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
  • Na J; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Engel JA; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Soon MSF; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Singh B; School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
  • Kueh AJ; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Herold MJ; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Montes de Oca M; School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
  • Singh SS; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Bunn PT; School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
  • Aguilera AR; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Casey M; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Braun M; School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
  • Ghazanfari N; Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
  • Wani S; Division of Blood Cells and Blood Cancer, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
  • Wang Y; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
  • Amante FH; Division of Blood Cells and Blood Cancer, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
  • Edwards CL; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
  • Haque A; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Dougall WC; Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
  • Singh OP; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Baxter AG; Institute of Glycomics, Griffith University, Gold Coast, Queensland, Australia.
  • Teng MWL; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Loukas A; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Daly NL; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Cloonan N; Department of Microbiology and Immunology, The Peter Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.
  • Degli-Esposti MA; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Uzonna J; Institute of Molecular Biology, University of Queensland, Brisbane, Queensland, Australia.
  • Heath WR; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Bald T; School of Environment and Science, Griffith University, Nathan, Queensland, Australia.
  • Tey SK; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Nakamura K; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Hill GR; School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
  • Kumar R; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Sundar S; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Smyth MJ; Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, India.
  • Engwerda CR; College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia.
Nat Immunol ; 21(10): 1205-1218, 2020 10.
Article en En | MEDLINE | ID: mdl-32839608
ABSTRACT
Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we show that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases. NKG7 expressed by CD4+ and CD8+ T cells played key roles in promoting inflammation during visceral leishmaniasis and malaria-two important parasitic diseases. Additionally, NKG7 expressed by natural killer cells was critical for controlling cancer initiation, growth and metastasis. NKG7 function in natural killer and CD8+ T cells was linked with their ability to regulate the translocation of CD107a to the cell surface and kill cellular targets, while NKG7 also had a major impact on CD4+ T cell activation following infection. Thus, we report a novel therapeutic target expressed on a range of immune cells with functions in different immune responses.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plasmodium / Leishmania donovani / Células Asesinas Naturales / Linfocitos T CD4-Positivos / Linfocitos T CD8-positivos / Inflamación / Leishmaniasis Visceral / Malaria / Proteínas de la Membrana Límite: Animals / Humans Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Australia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plasmodium / Leishmania donovani / Células Asesinas Naturales / Linfocitos T CD4-Positivos / Linfocitos T CD8-positivos / Inflamación / Leishmaniasis Visceral / Malaria / Proteínas de la Membrana Límite: Animals / Humans Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Australia