Increased Burden of Rare Sequence Variants in GnRH-Associated Genes in Women With Hypothalamic Amenorrhea.
J Clin Endocrinol Metab
; 106(3): e1441-e1452, 2021 03 08.
Article
en En
| MEDLINE
| ID: mdl-32870266
ABSTRACT
CONTEXT Functional hypothalamic amenorrhea (HA) is a common, acquired form of hypogonadotropic hypogonadism that occurs in the setting of energy deficits and/or stress. Variability in individual susceptibility to these stressors, HA heritability, and previous identification of several rare sequence variants (RSVs) in genes associated with the rare disorder, isolated hypogonadotropic hypogonadism (IHH), in individuals with HA suggest a possible genetic contribution to HA susceptibility. OBJECTIVE:
We sought to determine whether the burden of RSVs in IHH-related genes is greater in women with HA than controls.DESIGN:
We compared patients with HA to control women.SETTING:
The study was conducted at secondary referral centers. PATIENTS AND OTHERPARTICIPANTS:
Women with HA (nâ =â 106) and control women (ClinSeq study; nâ =â 468).INTERVENTIONS:
We performed exome sequencing in all patients and controls. MAIN OUTCOME MEASURE(S) The frequency of RSVs in 53 IHH-associated genes was determined using rare variant burden and association tests.RESULTS:
RSVs were overrepresented in women with HA compared with controls (Pâ =â .007). Seventy-eight heterozygous RSVs in 33 genes were identified in 58 women with HA (36.8% of alleles) compared to 255 RSVs in 41 genes among 200 control women (27.2%).CONCLUSIONS:
Women with HA are enriched for RSVs in genes that cause IHH, suggesting that variation in genes associated with gonadotropin-releasing hormone neuronal ontogeny and function may be a major determinant of individual susceptibility to developing HA in the face of diet, exercise, and/or stress.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hormona Liberadora de Gonadotropina
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Amenorrea
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Enfermedades Hipotalámicas
Tipo de estudio:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
J Clin Endocrinol Metab
Año:
2021
Tipo del documento:
Article