Inhibitory and inductive effects of 4- or 5-methyl-2-mercaptobenzimidazole, thyrotoxic and hepatotoxic rubber antioxidants, on several forms of cytochrome P450 in primary cultured rat and human hepatocytes.

Miyajima, Atsuko; Kuroda, Yukie; Sakemi-Hoshikawa, Kazue; Usami, Makoto; Mitsunaga, Katsuyoshi; Irie, Tomohiko; Ohno, Yasuo; Sunouchi, Momoko

Miyajima, Atsuko; Kuroda, Yukie; Sakemi-Hoshikawa, Kazue; Usami, Makoto; Mitsunaga, Katsuyoshi; Irie, Tomohiko; Ohno, Yasuo; Sunouchi, Momoko.

Afiliación

Miyajima A; Division of Medical Devices, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.
Kuroda Y; Division of Pharmacology, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.
Sakemi-Hoshikawa K; Division of Pharmacology, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.
Usami M; Division of Pharmacology, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.
Mitsunaga K; Graduate School of Veterinary Medicine, Azabu University, 1-17-1, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa, 252-5201, Japan.
Irie T; School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba, 274-8510, Japan.
Ohno Y; Division of Pharmacology, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.
Sunouchi M; Division of Pharmacology, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.

Toxicol Rep ; 7: 979-985, 2020.

Article en En | MEDLINE | ID: mdl-32874920

Palabras clave

3-MC, 3-methylcholanthrene; 4(5)-MeMBI, 4(or 5)-methyl-2-mercaptobenzimidazole; 4-MeMBI, 4-methyl-2-mercaptobenzimidazole; 5-MeMBI, 5-methyl-2-mercaptobenzimidazole; AhR, aryl hydrocarbon receptor; Benzimidazole; CYP, cytochrome P450; Cytochrome P450; DMSO, dimethyl sulfoxide; Drug-metabolizing activity; EROD, 7-ethoxyresorufin O-deethylation; Hepatocyte; MBI, 2-mercaptobenzimidazole; PXR, pregnane X receptor; Primary culture; T6ßH, testosterone 6ß-hydroxylation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Toxicol Rep Año: 2020 Tipo del documento: Article País de afiliación: Japón

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