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Hydroxypropyl-ß-cyclodextrin as an effective carrier of curcumin - piperine nutraceutical system with improved enzyme inhibition properties.
Stasilowicz, Anna; Tykarska, Ewa; Lewandowska, Kornelia; Kozak, Maciej; Miklaszewski, Andrzej; Kobus-Cisowska, Joanna; Szymanowska, Daria; Plech, Tomasz; Jenczyk, Jacek; Cielecka-Piontek, Judyta.
Afiliación
  • Stasilowicz A; Department of Pharmacognosy, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
  • Tykarska E; Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Poznan, Poland.
  • Lewandowska K; Department of Molecular Crystals Institute, Molecular Physics Polish Academy Sciences, Poznan, Poland.
  • Kozak M; Department of Macromolecular Physics, Adam Mickiewicz University in Poznan, Poznan, Poland.
  • Miklaszewski A; Division of Functional Nanomaterials, Poznan University of Technology, Poznan, Poland.
  • Kobus-Cisowska J; Department of Gastronomy Sciences and Functional Foods, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, Poznan, Poland.
  • Szymanowska D; Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, Poznan, Poland.
  • Plech T; Department of Pharmacology, Medical University of Lublin, Lublin, Poland.
  • Jenczyk J; NanoBioMedical Centre, Adam Mickiewicz University, Poznan, Poland.
  • Cielecka-Piontek J; Department of Pharmacognosy, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
J Enzyme Inhib Med Chem ; 35(1): 1811-1821, 2020 Dec.
Article en En | MEDLINE | ID: mdl-32967477
ABSTRACT
The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-ß-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-ß-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin-piperine system, its permeability through biological membranes (gastrointestinal tract, blood-brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperidinas / Acetilcolinesterasa / Butirilcolinesterasa / Portadores de Fármacos / Inhibidores de la Colinesterasa / Curcumina / Alcaloides / Benzodioxoles / Alcamidas Poliinsaturadas / 2-Hidroxipropil-beta-Ciclodextrina Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Polonia
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperidinas / Acetilcolinesterasa / Butirilcolinesterasa / Portadores de Fármacos / Inhibidores de la Colinesterasa / Curcumina / Alcaloides / Benzodioxoles / Alcamidas Poliinsaturadas / 2-Hidroxipropil-beta-Ciclodextrina Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Polonia