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Systematically explore the potential hepatotoxic material basis and molecular mechanism of Radix Aconiti Lateralis based on the concept of toxicological evidence chain (TEC).
Zhang, Kai; Liu, Chuanxin; Yang, Tiange; Li, Xinxin; Wei, Longyin; Chen, Dongling; Zhou, Jiali; Yin, Yihui; Yu, Xinyu; Li, Fei.
Afiliación
  • Zhang K; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Liangxiang Town, Fangshan District, Beijing, 102488, China.
  • Liu C; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Liangxiang Town, Fangshan District, Beijing, 102488, China.
  • Yang T; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Liangxiang Town, Fangshan District, Beijing, 102488, China.
  • Li X; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Liangxiang Town, Fangshan District, Beijing, 102488, China.
  • Wei L; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Liangxiang Town, Fangshan District, Beijing, 102488, China.
  • Chen D; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Liangxiang Town, Fangshan District, Beijing, 102488, China.
  • Zhou J; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Liangxiang Town, Fangshan District, Beijing, 102488, China.
  • Yin Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Liangxiang Town, Fangshan District, Beijing, 102488, China.
  • Yu X; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Liangxiang Town, Fangshan District, Beijing, 102488, China.
  • Li F; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Liangxiang Town, Fangshan District, Beijing, 102488, China. Electronic address: 602110@bucm.edu.cn.
Ecotoxicol Environ Saf ; 205: 111342, 2020 Dec 01.
Article en En | MEDLINE | ID: mdl-32971455
Radix aconiti lateralis (Fuzi) is widely used in China as a traditional Chinese medicine for the treatment of asthenia, pain and inflammation. However, its toxic alkaloids often lead to adverse reactions. Currently, most of the toxicity studies on Fuzi are focused on the heart and nervous system, and more comprehensive toxicity studies are needed. In this study, based on the previous reports of Fuzi hepatotoxicity, serum pharmacochemistry and network toxicology were used to screen the potential toxic components of Heishunpian(HSP), a processed product of Fuzi, and to explore the possible mechanism of HSP-induced hepatotoxicity. The results obtained are expressed based on the toxicological evidence chain (TEC). It was found that 22 potential toxic components screened can affect Th17 cell differentiation, Jak-STAT signaling pathway, glutathione metabolism, and other related pathways by regulating AKT1, IL2, F2, GSR, EGFR and other related targets, which induces oxidative stress, metabolic disorders, cell apoptosis, immune response, and excessive release of inflammatory factors, eventually inducing liver damage in rats. This is the first study on HSP-induced hepatotoxicity based on the TEC concept, providing references for further studies on the toxicity mechanism of Fuzi.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Aconitum / Alcaloides / Enfermedad Hepática Inducida por Sustancias y Drogas / Modelos Biológicos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Ecotoxicol Environ Saf Año: 2020 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Aconitum / Alcaloides / Enfermedad Hepática Inducida por Sustancias y Drogas / Modelos Biológicos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Ecotoxicol Environ Saf Año: 2020 Tipo del documento: Article País de afiliación: China