Your browser doesn't support javascript.
loading
SARS-CoV-2 antibody signatures robustly predict diverse antiviral functions relevant for convalescent plasma therapy.
Natarajan, Harini; Crowley, Andrew R; Butler, Savannah E; Xu, Shiwei; Weiner, Joshua A; Bloch, Evan M; Littlefield, Kirsten; Wieland-Alter, Wendy; Connor, Ruth I; Wright, Peter F; Benner, Sarah E; Bonny, Tania S; Laeyendecker, Oliver; Sullivan, David; Shoham, Shmuel; Quinn, Thomas C; Larman, H Benjamin; Casadevall, Arturo; Pekosz, Andrew; Redd, Andrew D; Tobian, Aaron A R; Ackerman, Margaret E.
Afiliación
  • Natarajan H; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, NH, USA.
  • Crowley AR; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, NH, USA.
  • Butler SE; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, NH, USA.
  • Xu S; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.
  • Weiner JA; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.
  • Bloch EM; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Littlefield K; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Wieland-Alter W; Department of Pediatrics, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
  • Connor RI; Department of Pediatrics, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
  • Wright PF; Department of Pediatrics, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
  • Benner SE; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Bonny TS; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Laeyendecker O; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Sullivan D; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Shoham S; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Quinn TC; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Larman HB; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Casadevall A; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Pekosz A; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Redd AD; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Tobian AAR; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Ackerman ME; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
medRxiv ; 2020 Sep 18.
Article en En | MEDLINE | ID: mdl-32995801
Convalescent plasma has emerged as a promising COVID-19 treatment. However, the humoral factors that contribute to efficacy are poorly understood. This study functionally and phenotypically profiled plasma from eligible convalescent donors. In addition to viral neutralization, convalescent plasma contained antibodies capable of mediating such Fc-dependent functions as complement activation, phagocytosis and antibody-dependent cellular cytotoxicity against SARS-CoV-2. These activities expand the antiviral functions associated with convalescent plasma and together with neutralization efficacy, could be accurately and robustly from antibody phenotypes. These results suggest that high-throughput profiling could be used to screen donors and plasma may provide benefits beyond neutralization.
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: MedRxiv Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: MedRxiv Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos