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Effect of fluoride in drinking water on the level of 5-methylcytosine in human and rat blood.
Meng, Xinyue; Yao, Yingjie; Ma, Yongzheng; Zhong, Nan; Alphonse, Sowanou; Pei, Junrui.
Afiliación
  • Meng X; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang Province, China.
  • Yao Y; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang Province, China.
  • Ma Y; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang Province, China.
  • Zhong N; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang Province, China.
  • Alphonse S; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang Province, China.
  • Pei J; Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang Province, China. Electronic address: pjr2
Environ Toxicol Pharmacol ; 81: 103511, 2021 Jan.
Article en En | MEDLINE | ID: mdl-33035703
ABSTRACT
DNA methylation is an epigenetic modification of genome that is involved in many human diseases. Recent studies revealed DNA methylation may be associated with fluorosis. This study was aimed to evaluate the dose-response effect of fluoride on DNA methylation in human and rat blood. A commercial ELISA kit was employed to evaluate 5-methylcytosine (5-mC) level of genome in human and rat blood. A total of 281 subjects were enrolled in this study and divided into four equal-size groups by the quartile of fluoride in drinking water. The difference of 5-mC among the four groups was significant. The U-shaped relationship was found between fluoride and 5-mC in the population. The U-shaped curve was also observed in the rats with three months of fluoride treatments. Taken together, these results clue the disruption of DNA methylation in mammals may has a certain association with fluoride in natural exposures.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Agua Potable / Metilación de ADN / 5-Metilcitosina / Fluoruros Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Environ Toxicol Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Agua Potable / Metilación de ADN / 5-Metilcitosina / Fluoruros Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Environ Toxicol Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: China