IL-7Rαlow CD8+ T Cells from Healthy Individuals Are Anergic with Defective Glycolysis.
J Immunol
; 205(11): 2968-2978, 2020 12 01.
Article
en En
| MEDLINE
| ID: mdl-33106337
ABSTRACT
Effector memory (EM) CD8+ T cells expressing lower levels of IL-7R α (IL-7Rαlow) from healthy individuals are partly compromised in vitro, but the identity of these cells has remained unclear. In this study, we demonstrate that human IL-7Rαlow EM CD8+ T cells are naturally occurring anergic cells in vivo and impaired in proliferation and IL-2 production but competent in IFN-γ and TNF-α production, a state that can be restored by IL-2 stimulation. IL-7Rαlow EM CD8+ T cells show decreased expression of GATA3 and c-MYC and are defective in metabolic reprogramming toward glycolysis, a process required for the proliferation of T cells. However, IL-7Rαlow EM CD8+ T cells can proliferate with TCR stimulation in the presence of IL-2 and IL-15, suggesting that these cells can be restored to normality or increased activity by inflammatory conditions and may serve as a reservoir for functional immunity.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T CD8-positivos
/
Receptores de Interleucina-7
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Glucólisis
Límite:
Humans
Idioma:
En
Revista:
J Immunol
Año:
2020
Tipo del documento:
Article