A novel dopamine D3R agonist SK609 with norepinephrine transporter inhibition promotes improvement in cognitive task performance in rodent and non-human primate models of Parkinson's disease.

Schneider, Jay S; Marshall, Courtney A; Keibel, Lauren; Snyder, Nathaniel W; Hill, Michael P; Brotchie, Jonathan M; Johnston, Tom H; Waterhouse, Barry D; Kortagere, Sandhya

Schneider, Jay S; Marshall, Courtney A; Keibel, Lauren; Snyder, Nathaniel W; Hill, Michael P; Brotchie, Jonathan M; Johnston, Tom H; Waterhouse, Barry D; Kortagere, Sandhya.

Afiliación

Schneider JS; Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Marshall CA; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
Keibel L; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
Snyder NW; Center for Metabolic Disease Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19147, USA.
Hill MP; Atuka Inc, Toronto, Ontario, Canada.
Brotchie JM; Atuka Inc, Toronto, Ontario, Canada.
Johnston TH; Atuka Inc, Toronto, Ontario, Canada.
Waterhouse BD; Department of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USA.
Kortagere S; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA. Electronic address: sk673@drexel.edu.

Exp Neurol ; 335: 113514, 2021 01.

Article en En | MEDLINE | ID: mdl-33141071

Asunto(s)

Butilaminas/farmacología; Agonistas de Dopamina/farmacología; Proteínas de Transporte de Noradrenalina a través de la Membrana Plasmática/antagonistas & inhibidores; Enfermedad de Parkinson/tratamiento farmacológico; Enfermedad de Parkinson/psicología; Desempeño Psicomotor/efectos de los fármacos; Receptores de Dopamina D3/agonistas; Animales; Atención/efectos de los fármacos; Encéfalo/metabolismo; Butilaminas/farmacocinética; Disfunción Cognitiva/inducido químicamente; Disfunción Cognitiva/tratamiento farmacológico; Disfunción Cognitiva/psicología; Hidroxidopaminas; Intoxicación por MPTP/tratamiento farmacológico; Macaca fascicularis; Masculino; Ratas; Ratas Sprague-Dawley

Palabras clave

6-OHDA unilateral lesion; Dopamine D3 receptor agonist; Mild cognitive impairment; Non-human primate model; Norepinephrine transporter inhibitor; Object retrieval task; Parkinson's disease; Pharmacokinetics; Prefrontal cortex; Sustained attention

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Desempeño Psicomotor / Butilaminas / Agonistas de Dopamina / Proteínas de Transporte de Noradrenalina a través de la Membrana Plasmática / Receptores de Dopamina D3 Límite: Animals Idioma: En Revista: Exp Neurol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google