The interactome of multifunctional HAX1 protein suggests its role in the regulation of energy metabolism, de-aggregation, cytoskeleton organization and RNA-processing.
Biosci Rep
; 40(11)2020 11 27.
Article
en En
| MEDLINE
| ID: mdl-33146709
ABSTRACT
HCLS1-associated protein X-1 (HAX1) is a multifunctional protein involved in many cellular processes, including apoptosis, cell migration and calcium homeostasis, but its mode of action still remains obscure. Multiple HAX1 protein partners have been identified, but they are involved in many distinct pathways, form different complexes and do not constitute a coherent group. By characterizing HAX1 protein interactome using targeted approach, we attempt to explain HAX1 multiple functions and its role in the cell. Presented analyses indicate that HAX1 interacts weakly with a wide spectrum of proteins and its interactome tends to be cell-specific, which conforms to a profile of intrinsically disordered protein (IDP). Moreover, we have identified a mitochondrial subset of HAX1 protein partners and preliminarily characterized its involvement in the cellular response to oxidative stress and aggregation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Citoesqueleto
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Neoplasias de la Mama
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Neoplasias del Cuello Uterino
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Procesamiento Postranscripcional del ARN
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Proteínas Adaptadoras Transductoras de Señales
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Metabolismo Energético
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Proteínas Intrínsecamente Desordenadas
Límite:
Female
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Humans
Idioma:
En
Revista:
Biosci Rep
Año:
2020
Tipo del documento:
Article
País de afiliación:
Polonia