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Remodeling of occluded internal carotid artery in vessel wall magnetic resonance imaging.
Zhou, Jun; Cai, Shi-Feng; Yuan, Xian-Shun; Pang, Zai-Ying; Yu, Bing-Xin; Yao, Hong; Xu, Jing-Jing; Pang, Yue-Jiu; Guo, Ning; Liu, Xue-Ping.
Afiliación
  • Zhou J; Department of Senile Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
  • Cai SF; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
  • Yuan XS; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
  • Pang ZY; Department of Senile Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
  • Yu BX; Department of Health Management, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Yao H; Department of Senile Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
  • Xu JJ; Department of Senile Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
  • Pang YJ; Department of Senile Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
  • Guo N; Department of Senile Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
  • Liu XP; Department of Senile Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Int J Neurosci ; 132(9): 860-867, 2022 Sep.
Article en En | MEDLINE | ID: mdl-33153335
ABSTRACT

OBJECTIVE:

The purpose of the present study was to investigate the remodeling pattern of the extracranial occluded internal carotid artery (OICA) by vessel wall magnetic resonance imaging (VWI).

METHODS:

Thirty-nine atherosclerotic OICAs from 32 consecutive cases underwent 3-Tesla VWI to acquire pre- and post-contrast T1-weighted two-dimensional fluid-attenuated inversion recovery fast spin echo sequences. 25 symptomatic CAs exhibited ipsilateral downstream cerebral ischemia or ophthalmic artery embolism within last three months. The 14 remaining CAs were asymptomatic. Twenty-four CAs from 22 patients with atherosclerosis but no stenosis were recruited as control group. The outer wall area (OWA) was calculated based on the outer contour of the carotid artery drawn on the pre-contrast VWI. Negative remodeling was defined as a lower OWA compared to that of control group.

RESULTS:

Clinical characteristics including age, sex and vascular risk factors showed no significant difference between the occluded and control group. However, the OWA was lower in the occluded group than in the control group (0.63 versus 0.90 cm2, p = 0.004). For all OICAs, the OWA was larger in symptomatic cases than asymptomatic cases (0.71 versus 0.49cm2, p = 0.025). Using a cutoff value of 0.44, the sensitivity and specificity of OWA for detecting symptomatic OICA were 0.88 and 0.57, respectively. Heterogeneous signal intensity and enhancement were more often observed at the proximal than the distal segment of occlusion (p < 0.001). The inter-observer agreement regarding the evaluation of VWI characteristics was desirable (κ = 0.805 ∼ 0.847).

CONCLUSIONS:

Negative remodeling is prevalent in OICA, especially in asymptomatic cases.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Isquemia Encefálica / Estenosis Carotídea Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Neurosci Año: 2022 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Isquemia Encefálica / Estenosis Carotídea Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Neurosci Año: 2022 Tipo del documento: Article País de afiliación: China