Risk-Taking Behaviors in Huntington's Disease.
J Huntingtons Dis
; 9(4): 359-369, 2020.
Article
en En
| MEDLINE
| ID: mdl-33164940
ABSTRACT
BACKGROUND:
Risky behaviors are common in Huntington's disease (HD) and can lead to significant adverse consequences. However, the prevalence and scope of these symptoms have not been studied systematically, and no empirically validated measures are available to screen for them.OBJECTIVE:
To test a novel screening tool designed to assess risk-taking behaviors in HD.METHODS:
We administered the Risk Behavior Questionnaire (RBQ-HD) to HD patients and caregivers at Vanderbilt University Medical Center between 2018-2019. Patients completed the questionnaire based on self-report; caregivers provided collateral reports. Clinical and demographic information were obtained from the electronic medical record.RESULTS:
60 patients and 60 caregivers completed the RBQ-HD. 80% of patients (nâ=â48) and 91.7% of caregivers (nâ=â60) reported at least one risky behavior. Adverse social behaviors, impulsive/compulsive behaviors, and reckless driving were the most common behavioral domains reported. Male patients were more likely to report risky behaviors than females (92.3% vs. 70.6%, pâ=â0.04). The number of risky behaviors reported by patients and caregivers was negatively correlated with patient age (râ=â-0.32, pâ=â0.01; râ=â-0.47, pâ=â0.0001, respectively). Patient and caregiver reports were highly correlated in matched pairs (nâ=â30; râ=â0.63, pâ=â0.0002).CONCLUSION:
These findings emphasize that risky behaviors are highly prevalent in HD and can be effectively identified through the use of a novel screening measure. We hypothesize that early pathological involvement of frontostriatal and mesolimbic networks may be important factors in the development of these behaviors.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Asunción de Riesgos
/
Conducta Social
/
Conducción de Automóvil
/
Enfermedad de Huntington
/
Conducta Compulsiva
/
Trastornos Relacionados con Sustancias
/
Conducta Impulsiva
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
/
Screening_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Huntingtons Dis
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos