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MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations.
Rath, Sneha; Sharma, Rohit; Gupta, Rahul; Ast, Tslil; Chan, Connie; Durham, Timothy J; Goodman, Russell P; Grabarek, Zenon; Haas, Mary E; Hung, Wendy H W; Joshi, Pallavi R; Jourdain, Alexis A; Kim, Sharon H; Kotrys, Anna V; Lam, Stephanie S; McCoy, Jason G; Meisel, Joshua D; Miranda, Maria; Panda, Apekshya; Patgiri, Anupam; Rogers, Robert; Sadre, Shayan; Shah, Hardik; Skinner, Owen S; To, Tsz-Leung; Walker, Melissa A; Wang, Hong; Ward, Patrick S; Wengrod, Jordan; Yuan, Chen-Ching; Calvo, Sarah E; Mootha, Vamsi K.
Afiliación
  • Rath S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Sharma R; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Gupta R; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Ast T; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Chan C; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Durham TJ; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Goodman RP; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Grabarek Z; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Haas ME; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Hung WHW; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Joshi PR; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Jourdain AA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Kim SH; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Kotrys AV; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Lam SS; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • McCoy JG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Meisel JD; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Miranda M; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Panda A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Patgiri A; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Rogers R; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Sadre S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Shah H; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Skinner OS; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • To TL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Walker MA; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Wang H; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Ward PS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Wengrod J; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Yuan CC; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Calvo SE; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Mootha VK; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Nucleic Acids Res ; 49(D1): D1541-D1547, 2021 01 08.
Article en En | MEDLINE | ID: mdl-33174596
The mammalian mitochondrial proteome is under dual genomic control, with 99% of proteins encoded by the nuclear genome and 13 originating from the mitochondrial DNA (mtDNA). We previously developed MitoCarta, a catalogue of over 1000 genes encoding the mammalian mitochondrial proteome. This catalogue was compiled using a Bayesian integration of multiple sequence features and experimental datasets, notably protein mass spectrometry of mitochondria isolated from fourteen murine tissues. Here, we introduce MitoCarta3.0. Beginning with the MitoCarta2.0 inventory, we performed manual review to remove 100 genes and introduce 78 additional genes, arriving at an updated inventory of 1136 human genes. We now include manually curated annotations of sub-mitochondrial localization (matrix, inner membrane, intermembrane space, outer membrane) as well as assignment to 149 hierarchical 'MitoPathways' spanning seven broad functional categories relevant to mitochondria. MitoCarta3.0, including sub-mitochondrial localization and MitoPathway annotations, is freely available at http://www.broadinstitute.org/mitocarta and should serve as a continued community resource for mitochondrial biology and medicine.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteoma / Proteínas Mitocondriales / Bases de Datos de Proteínas / Anotación de Secuencia Molecular / Mitocondrias Límite: Animals / Humans Idioma: En Revista: Nucleic Acids Res Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteoma / Proteínas Mitocondriales / Bases de Datos de Proteínas / Anotación de Secuencia Molecular / Mitocondrias Límite: Animals / Humans Idioma: En Revista: Nucleic Acids Res Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos