A marine microbiome antifungal targets urgent-threat drug-resistant fungi.
Science
; 370(6519): 974-978, 2020 11 20.
Article
en En
| MEDLINE
| ID: mdl-33214279
ABSTRACT
New antifungal drugs are urgently needed to address the emergence and transcontinental spread of fungal infectious diseases, such as pandrug-resistant Candida auris. Leveraging the microbiomes of marine animals and cutting-edge metabolomics and genomic tools, we identified encouraging lead antifungal molecules with in vivo efficacy. The most promising lead, turbinmicin, displays potent in vitro and mouse-model efficacy toward multiple-drug-resistant fungal pathogens, exhibits a wide safety index, and functions through a fungal-specific mode of action, targeting Sec14 of the vesicular trafficking pathway. The efficacy, safety, and mode of action distinct from other antifungal drugs make turbinmicin a highly promising antifungal drug lead to help address devastating global fungal pathogens such as C. auris.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Urocordados
/
Benzopiranos
/
Candida
/
Farmacorresistencia Fúngica Múltiple
/
Candidiasis Invasiva
/
Isoquinolinas
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Micromonospora
/
Antifúngicos
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos