Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study.
J Alzheimers Dis
; 79(1): 117-125, 2021.
Article
en En
| MEDLINE
| ID: mdl-33216038
ABSTRACT
BACKGROUND:
The Long Life Family Study (LLFS) is a family based, prospective study of healthy aging and familial longevity. The study includes two assessments of cognitive function that were administered approximately 8 years apart.OBJECTIVE:
To test whether APOE genotype is associated with change of cognitive function in older adults.METHODS:
We used Bayesian hierarchical models to test the association between APOE alleles and change of cognitive function. Six longitudinally collected neuropsychological test scores were modelled as a function of age at enrollment, follow-up time, gender, education, field center, birth cohort indicator (≤1935, or >1935), and the number of copies of É2 or É4 alleles.RESULTS:
Out of 4,587 eligible participants, 2,064 were male (45.0%), and age at enrollment ranged from 25 to 110 years, with mean of 70.85 years (SD 15.75). We detected a significant cross-sectional effect of the APOEÉ4 allele on Logical Memory. Participants carrying at least one copy of the É4 allele had lower scores in both immediate (-0.31 points, 95% CI -0.57, -0.05) and delayed (-0.37 points, 95% CI -0.64, -0.10) recall comparing to non-É4 allele carriers. We did not detect any significant longitudinal effect of the É4 allele. There was no cross-sectional or longitudinal effect of the É2 allele.CONCLUSION:
The APOEÉ4 allele was identified as a risk factor for poorer episodic memory in older adults, while the APOEÉ2 allele was not significantly associated with any of the cognitive test scores.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Atención
/
Cognición
/
Apolipoproteína E2
/
Apolipoproteína E3
/
Apolipoproteína E4
/
Envejecimiento Cognitivo
/
Memoria
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Alzheimers Dis
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos