Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway.

Phan, Thao P; Maryniak, Aubrey L; Boatwright, Christina A; Lee, Junsu; Atkins, Alisa; Tijhuis, Andrea; Spierings, Diana Cj; Bazzi, Hisham; Foijer, Floris; Jordan, Philip W; Stracker, Travis H; Holland, Andrew J

Phan, Thao P; Maryniak, Aubrey L; Boatwright, Christina A; Lee, Junsu; Atkins, Alisa; Tijhuis, Andrea; Spierings, Diana Cj; Bazzi, Hisham; Foijer, Floris; Jordan, Philip W; Stracker, Travis H; Holland, Andrew J.

Afiliación

Phan TP; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Maryniak AL; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Boatwright CA; Johns Hopkins University, Baltimore, MD, USA.
Lee J; Johns Hopkins University, Baltimore, MD, USA.
Atkins A; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Tijhuis A; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Spierings DC; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Bazzi H; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Foijer F; Department of Dermatology and Venereology, University Hospital of Cologne, Köln, Germany.
Jordan PW; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Stracker TH; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Holland AJ; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.

EMBO J ; 40(1): e106118, 2021 01 04.

Article en En | MEDLINE | ID: mdl-33226141

Asunto(s)

Centrosoma/metabolismo; Microcefalia/genética; Microcefalia/metabolismo; Mitosis/genética; Proteína p53 Supresora de Tumor/genética; Proteína 1 de Unión al Supresor Tumoral P53/genética; Ubiquitina Tiolesterasa/genética; Animales; Apoptosis/genética; Encéfalo/patología; Muerte Celular/genética; Proliferación Celular/genética; Células Cultivadas; Ratones; Ratones Noqueados; Mutación/genética; Transducción de Señal/genética

Palabras clave

DNA damage; TP53 activation; centrosome; microcephaly; mitotic surveillance pathway

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Centrosoma / Ubiquitina Tiolesterasa / Proteína 1 de Unión al Supresor Tumoral P53 / Microcefalia / Mitosis Tipo de estudio: Screening_studies Límite: Animals Idioma: En Revista: EMBO J Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google