Your browser doesn't support javascript.
loading
Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19.
Rodda, Lauren B; Netland, Jason; Shehata, Laila; Pruner, Kurt B; Morawski, Peter A; Thouvenel, Christopher D; Takehara, Kennidy K; Eggenberger, Julie; Hemann, Emily A; Waterman, Hayley R; Fahning, Mitchell L; Chen, Yu; Hale, Malika; Rathe, Jennifer; Stokes, Caleb; Wrenn, Samuel; Fiala, Brooke; Carter, Lauren; Hamerman, Jessica A; King, Neil P; Gale, Michael; Campbell, Daniel J; Rawlings, David J; Pepper, Marion.
Afiliación
  • Rodda LB; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Netland J; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Shehata L; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Pruner KB; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Morawski PA; Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA 98101, USA.
  • Thouvenel CD; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101, USA.
  • Takehara KK; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Eggenberger J; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.
  • Hemann EA; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.
  • Waterman HR; Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA 98101, USA.
  • Fahning ML; Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA 98101, USA.
  • Chen Y; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101, USA.
  • Hale M; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101, USA.
  • Rathe J; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.
  • Stokes C; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.
  • Wrenn S; Department of Biochemistry, University of Washington, Seattle, WA, USA, 98195 and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Fiala B; Department of Biochemistry, University of Washington, Seattle, WA, USA, 98195 and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Carter L; Department of Biochemistry, University of Washington, Seattle, WA, USA, 98195 and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Hamerman JA; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA; Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA 98101, USA.
  • King NP; Department of Biochemistry, University of Washington, Seattle, WA, USA, 98195 and Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Gale M; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA.
  • Campbell DJ; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA; Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA 98101, USA.
  • Rawlings DJ; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101, USA.
  • Pepper M; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA. Electronic address: mpepper@uw.edu.
Cell ; 184(1): 169-183.e17, 2021 01 07.
Article en En | MEDLINE | ID: mdl-33296701
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a global pandemic, and cases continue to rise. Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could contribute to immunity. We performed a longitudinal assessment of individuals recovered from mild COVID-19 to determine whether they develop and sustain multifaceted SARS-CoV-2-specific immunological memory. Recovered individuals developed SARS-CoV-2-specific immunoglobulin (IgG) antibodies, neutralizing plasma, and memory B and memory T cells that persisted for at least 3 months. Our data further reveal that SARS-CoV-2-specific IgG memory B cells increased over time. Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral function memory T cells secreted cytokines and expanded upon antigen re-encounter, whereas memory B cells expressed receptors capable of neutralizing virus when expressed as monoclonal antibodies. Therefore, mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 / Memoria Inmunológica Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 / Memoria Inmunológica Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos