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New Associations between Drug-Induced Adverse Events in Animal Models and Humans Reveal Novel Candidate Safety Targets.
Giblin, Kathryn A; Basili, Danilo; Afzal, Avid M; Rosenbrier-Ribeiro, Lyn; Greene, Nigel; Barrett, Ian; Hughes, Samantha J; Bender, Andreas.
Afiliación
  • Giblin KA; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
  • Basili D; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Afzal AM; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
  • Rosenbrier-Ribeiro L; Data Sciences and Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Greene N; Safety Platforms, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Barrett I; Data Science and Artificial Intelligence, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Boston, Massachusetts 02451, United States.
  • Hughes SJ; Data Sciences and Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Bender A; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
Chem Res Toxicol ; 34(2): 438-451, 2021 02 15.
Article en En | MEDLINE | ID: mdl-33338378
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Sistemas de Registro de Reacción Adversa a Medicamentos Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Chem Res Toxicol Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Sistemas de Registro de Reacción Adversa a Medicamentos Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Chem Res Toxicol Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido