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Differential effects of bile acids on the postprandial secretion of gut hormones: a randomized crossover study.
McGlone, Emma Rose; Malallah, Khalefah; Cuenco, Joyceline; Wewer Albrechtsen, Nicolai J; Holst, Jens J; Vincent, Royce P; Ling, Charlotte; Khan, Omar A; Verma, Surabhi; Ahmed, Ahmed R; Walters, Julian R F; Khoo, Bernard; Bloom, Stephen R; Tan, Tricia M M.
Afiliación
  • McGlone ER; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
  • Malallah K; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
  • Cuenco J; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
  • Wewer Albrechtsen NJ; Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Holst JJ; NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Vincent RP; Department of Biomedical Sciences and the NNF Center for Basic Metabolic Research, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.
  • Ling C; Department of Biomedical Sciences and the NNF Center for Basic Metabolic Research, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.
  • Khan OA; Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, London, United Kingdom.
  • Verma S; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
  • Ahmed AR; Department of Surgery, St. George's University Hospitals NHS Trust, London, United Kingdom.
  • Walters JRF; Leadiant Biosciences, Amberley House, Windsor, Berkshire, United Kingdom.
  • Khoo B; Department of Surgery and Cancer, Imperial College Healthcare NHS Trust, London, United Kingdom.
  • Bloom SR; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
  • Tan TMM; Endocrinology, UCL Division of Medicine, Royal Free Hospital, London, United Kingdom.
Am J Physiol Endocrinol Metab ; 320(4): E671-E679, 2021 04 01.
Article en En | MEDLINE | ID: mdl-33459181
ABSTRACT
Bile acids (BA) regulate postprandial metabolism directly and indirectly by affecting the secretion of gut hormones like glucagon-like peptide-1 (GLP-1). The postprandial effects of BA on the secretion of other metabolically active hormones are not well understood. The objective of this study was to investigate the effects of oral ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) on postprandial secretion of GLP-1, oxyntomodulin (OXM), peptide YY (PYY), glucose-dependent insulinotropic peptide (GIP), glucagon, and ghrelin. Twelve healthy volunteers underwent a mixed meal test 60 min after ingestion of UDCA (12-16 mg/kg), CDCA (13-16 mg/kg), or no BA in a randomized crossover study. Glucose, insulin, GLP-1, OXM, PYY, GIP, glucagon, ghrelin, and fibroblast growth factor 19 were measured prior to BA administration at -60 and 0 min (just prior to mixed meal) and 15, 30, 60, 120, 180, and 240 min after the meal. UDCA and CDCA provoked differential gut hormone responses; UDCA did not have any significant effects, but CDCA provoked significant increases in GLP-1 and OXM and a profound reduction in GIP. CDCA increased fasting GLP-1 and OXM secretion in parallel with an increase in insulin. On the other hand, CDCA reduced postprandial secretion of GIP, with an associated reduction in postprandial insulin secretion. Exogenous CDCA can exert multiple salutary effects on the secretion of gut hormones; if these effects are confirmed in obesity and type 2 diabetes, CDCA may be a potential therapy for these conditions.NEW & NOTEWORTHY Oral CDCA and UDCA have different effects on gut and pancreatic hormone secretion. A single dose of CDCA increased fasting secretion of the hormones GLP-1 and OXM with an accompanying increase in insulin secretion. CDCA also reduced postprandial GIP secretion, which was associated with reduced insulin. In contrast, UDCA did not change gut hormone secretion fasting or postprandially. Oral CDCA could be beneficial to patients with obesity and diabetes.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácidos y Sales Biliares / Periodo Posprandial / Hormonas Gastrointestinales Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Am J Physiol Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácidos y Sales Biliares / Periodo Posprandial / Hormonas Gastrointestinales Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Am J Physiol Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido