S100/CD34-Positive Spindle Cell Mesenchymal Neoplasm Harboring KIAA1549-BRAF Fusion.
Am J Dermatopathol
; 43(3): 217-220, 2021 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-33464748
ABSTRACT
ABSTRACT Mesenchymal neoplasms with oncogenic kinase activity due to genomic alterations in receptor tyrosine kinase genes are a morphologically heterogeneous group with a variable biologic potential. A subset of these neoplasms are characterized by immunophenotypic property of dual S100 protein/CD34 expression, histopathological resemblance to lipofibromatosis or peripheral nerve sheath tumors, and often alterations in neurotrophic tropomyosin-related kinase genes. In this article, we present a case of an S100 protein/CD34-positive spindle cell neoplasm harboring a rare BRAF gene rearrangement (KIAA1549-BRAF fusion) and discuss the clinical, histopathological, and molecular variations associated with such neoplasms.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Proteínas de Fusión Oncogénica
/
Proteínas Proto-Oncogénicas B-raf
/
Proteínas de la Membrana
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Dermatopathol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Australia