Effect of Mechanical Strain on Cells Involved in Fracture Healing.
Orthop Surg
; 13(2): 369-375, 2021 Apr.
Article
en En
| MEDLINE
| ID: mdl-33496077
ABSTRACT
Secondary fracture healing is a complex multi-stage process in which the mechanical environment plays a key role. The use of an appropriate mechanical stimulation such as strain is conducive to tissue formation between fracture ends, thus aiding the healing process. However, if the strain is too large or too small, the biological behavior of the cells involved in bone healing will be affected, resulting in non-union or delayed healing. In this review, we summarize the current state of knowledge regarding the effect of strain on cells that play a role in the fracture-healing process. Overall, the related literature suggests that selection of an adequate strain promotes fracture healing through the stimulation of angiogenesis and osteogenesis, along with inhibition of osteoclast differentiation and bone resorption. However, standardized methods for the application of mechanical stimulation are lacking, and a unified consensus on the mechanism by which strain promotes cell differentiation has not yet been reached. These issues, therefore, deserve further investigation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Estimulación Física
/
Estrés Mecánico
/
Curación de Fractura
/
Células del Tejido Conectivo
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Orthop Surg
Año:
2021
Tipo del documento:
Article
País de afiliación:
China