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Early middle age cholesterol levels and the association with age-related macular degeneration.
Kananen, Fabian; Strandberg, Timo; Loukovaara, Sirpa; Immonen, Ilkka.
Afiliación
  • Kananen F; University of Helsinki, Helsinki, Finland.
  • Strandberg T; Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden.
  • Loukovaara S; University of Helsinki, Helsinki, Finland.
  • Immonen I; Department of Geriatrics, Helsinki University Hospital, Helsinki, Finland.
Acta Ophthalmol ; 99(7): e1063-e1069, 2021 Nov.
Article en En | MEDLINE | ID: mdl-33533136
PURPOSE: To examine whether serum cholesterol in early middle age is associated with age-related macular degeneration (AMD) later in life. METHODS: A group of Helsinki Businessmen Study (HBS) participants (n = 209) were recruited for the study. Total cholesterol (TC), triglyceride and body mass index (BMI) were measured at the HBS baseline visit in 1964-1973. Lipid subfractions, BMI, smoking status and statin use were recorded in 2011 and fundus photographs graded for AMD in 2005-2012. The subjects were genotyped for the main AMD risk single nucleotide polymorphisms (SNPs). RESULTS: TC measured at baseline 1964-1973 was significantly higher in subjects later developing intermediate or late AMD (6.67 mmol/l versus 6.20 mmol/l, p = 0.024) or with drusen size of ≥125 µm (6.68 mmol/l versus 6.21 mmol/l, p = 0.030) compared with the rest of the study population. TC, LDL and TG values at follow-up 2011 were lower in subjects with AMD compared to those without, whereas HDL levels showed no difference. In multivariate analysis, baseline TC associated with intermediate or late AMD (OR 1.59, p = 0.004) and drusen size ≥ 125 µm (OR 1.57, p = 0.006) when corrected for age, BMI, AMD risk SNPs and smoking. Lipid values measured 2011 had no associations after correction. CONCLUSIONS: High systemic total cholesterol in early middle age may have a role in the initial development of AMD, especially in patients later developing large drusen.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Colesterol / Medición de Riesgo / Polimorfismo de Nucleótido Simple / Degeneración Macular Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Acta Ophthalmol Asunto de la revista: OFTALMOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Finlandia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Colesterol / Medición de Riesgo / Polimorfismo de Nucleótido Simple / Degeneración Macular Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Acta Ophthalmol Asunto de la revista: OFTALMOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Finlandia