Splice-Switching Antisense Oligonucleotides as a Targeted Intrinsic Engineering Tool for Generating Armored Redirected T Cells.

Ceccarello, Erica; Tabaglio, Tommaso; Koh, Sarene; Oei, Vincent; Teo, Winnie; Jonathan, Owen Julianto; Pavesi, Andrea; Chen, Qingfeng; Bertoletti, Antonio; Wee, Keng Boon; Guccione, Ernesto

Ceccarello, Erica; Tabaglio, Tommaso; Koh, Sarene; Oei, Vincent; Teo, Winnie; Jonathan, Owen Julianto; Pavesi, Andrea; Chen, Qingfeng; Bertoletti, Antonio; Wee, Keng Boon; Guccione, Ernesto.

Afiliación

Ceccarello E; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Tabaglio T; Duke-NUS Medical School, Singapore, Singapore.
Koh S; IMMUNOA Pte Ltd, Singapore, Singapore.
Oei V; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Teo W; Lion TCR Pte Ltd, Singapore, Singapore.
Jonathan OJ; Singapore Immunology Network, Agency for Science and Technology (A*STAR), Singapore, Singapore.
Pavesi A; Duke-NUS Medical School, Singapore, Singapore.
Chen Q; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Bertoletti A; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Wee KB; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Guccione E; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

Nucleic Acid Ther ; 31(2): 145-154, 2021 04.

Article en En | MEDLINE | ID: mdl-33567222

Asunto(s)

Supervivencia Celular/efectos de los fármacos; Oligonucleótidos Antisentido/farmacología; Linfocitos T/inmunología; Supervivencia Celular/inmunología; Exones/efectos de los fármacos; Exones/genética; Humanos; Mutación/genética; Oligonucleótidos Antisentido/genética; Oligonucleótidos Antisentido/inmunología; Empalme del ARN/genética; Empalme del ARN/inmunología; ARN Mensajero/genética; Linfocitos T/efectos de los fármacos

Palabras clave

HBV+HCC; TCR-redirected T cells; splice switching antisense oligonucleotides (SSOs)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos T / Supervivencia Celular / Oligonucleótidos Antisentido Límite: Humans Idioma: En Revista: Nucleic Acid Ther Año: 2021 Tipo del documento: Article País de afiliación: Singapur

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