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MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction.
Elman, Jeremy A; Puckett, Olivia K; Beck, Asad; Fennema-Notestine, Christine; Cross, Latonya K; Dale, Anders M; Eglit, Graham M L; Eyler, Lisa T; Gillespie, Nathan A; Granholm, Eric L; Gustavson, Daniel E; Hagler, Donald J; Hatton, Sean N; Hauger, Richard; Jak, Amy J; Logue, Mark W; McEvoy, Linda K; McKenzie, Ruth E; Neale, Michael C; Panizzon, Matthew S; Reynolds, Chandra A; Sanderson-Cimino, Mark; Toomey, Rosemary; Tu, Xin M; Whitsel, Nathan; Williams, McKenna E; Xian, Hong; Lyons, Michael J; Franz, Carol E; Kremen, William S.
Afiliación
  • Elman JA; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
  • Puckett OK; Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, California, USA.
  • Beck A; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
  • Fennema-Notestine C; Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, California, USA.
  • Cross LK; Graduate Program in Neuroscience, University of Washington, Seattle, Washington, USA.
  • Dale AM; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
  • Eglit GML; Department of Radiology, University of California San Diego, La Jolla, California, USA.
  • Eyler LT; Department of Psychology, University of Hawaii Hilo, Hilo, Hawaii, USA.
  • Gillespie NA; Department of Radiology, University of California San Diego, La Jolla, California, USA.
  • Granholm EL; Department of Neuroscience, University of California San Diego, La Jolla, California, USA.
  • Gustavson DE; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
  • Hagler DJ; Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, California, USA.
  • Hatton SN; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
  • Hauger R; Desert Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, California, USA.
  • Jak AJ; Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
  • Logue MW; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
  • McEvoy LK; VA San Diego Healthcare System, San Diego, California, USA.
  • McKenzie RE; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Neale MC; Department of Radiology, University of California San Diego, La Jolla, California, USA.
  • Panizzon MS; Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, California, USA.
  • Reynolds CA; Department of Neuroscience, University of California San Diego, La Jolla, California, USA.
  • Sanderson-Cimino M; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
  • Toomey R; VA San Diego Healthcare System, San Diego, California, USA.
  • Tu XM; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
  • Whitsel N; VA San Diego Healthcare System, San Diego, California, USA.
  • Williams ME; National Center for PTSD: Behavioral Science Division, VA Boston Healthcare System, Boston, Massachusetts, USA.
  • Xian H; Department of Psychiatry and the Biomedical Genetics Section, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Lyons MJ; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
  • Franz CE; Department of Radiology, University of California San Diego, La Jolla, California, USA.
  • Kremen WS; School of Education and Public Policy, Merrimack College, Andover, Massachusetts, USA.
Alzheimers Dement ; 17(6): 1017-1025, 2021 06.
Article en En | MEDLINE | ID: mdl-33580733
ABSTRACT

INTRODUCTION:

The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression.

METHODS:

Participants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin-sensitive magnetic resonance imaging (MRI) contrast-to-noise ratio (LCCNR ). We examined LCCNR , cognition, amnestic mild cognitive impairment (aMCI), and daytime dysfunction.

RESULTS:

Heritability of LCCNR was .48. Participants with aMCI showed greater daytime dysfunction. Lower LCCNR was associated with poorer episodic memory, general verbal fluency, semantic fluency, and processing speed, as well as increased odds of aMCI and greater daytime dysfunction.

DISCUSSION:

Reduced LC integrity is associated with widespread differences across cognitive domains, daytime sleep-related dysfunction, and risk for aMCI. These findings in late-middle-aged adults highlight the potential of MRI-based measures of LC integrity in early identification of AD risk.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Locus Coeruleus / Cognición / Disfunción Cognitiva Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male Idioma: En Revista: Alzheimers Dement Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Locus Coeruleus / Cognición / Disfunción Cognitiva Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male Idioma: En Revista: Alzheimers Dement Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos