Multitargeting application of proline-derived peptidomimetics addressing cancer-related human matrix metalloproteinase 9 and carbonic anhydrase II.

Lenci, Elena; Angeli, Andrea; Calugi, Lorenzo; Innocenti, Riccardo; Carta, Fabrizio; Supuran, Claudiu T; Trabocchi, Andrea

Lenci, Elena; Angeli, Andrea; Calugi, Lorenzo; Innocenti, Riccardo; Carta, Fabrizio; Supuran, Claudiu T; Trabocchi, Andrea.

Afiliación

Lenci E; Department of Chemistry "Ugo Schiff", University of Florence, Via Della Lastruccia 13, 50019, Sesto Fiorentino, Florence, Italy.
Angeli A; NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Chemistry, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Florence, Italy.
Calugi L; Department of Chemistry "Ugo Schiff", University of Florence, Via Della Lastruccia 13, 50019, Sesto Fiorentino, Florence, Italy.
Innocenti R; Department of Chemistry "Ugo Schiff", University of Florence, Via Della Lastruccia 13, 50019, Sesto Fiorentino, Florence, Italy.
Carta F; NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Chemistry, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Florence, Italy.
Supuran CT; NEUROFARBA Department, Section of Pharmaceutical and Nutraceutical Chemistry, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Florence, Italy. Electronic address: claudiu.supuran@unifi.it.
Trabocchi A; Department of Chemistry "Ugo Schiff", University of Florence, Via Della Lastruccia 13, 50019, Sesto Fiorentino, Florence, Italy; Interdepartmental Center for Preclinical Development of Molecular Imaging (CISPIM), University of Florence, Viale Morgagni 85, 50134, Florence, Italy. Electronic address:

Eur J Med Chem ; 214: 113260, 2021 Mar 15.

Article en En | MEDLINE | ID: mdl-33581552

Asunto(s)

Anhidrasa Carbónica II/antagonistas & inhibidores; Inhibidores de Anhidrasa Carbónica/farmacología; Metaloproteinasa 9 de la Matriz/metabolismo; Inhibidores de la Metaloproteinasa de la Matriz/farmacología; Peptidomiméticos/farmacología; Prolina/farmacología; Anhidrasa Carbónica II/metabolismo; Inhibidores de Anhidrasa Carbónica/síntesis química; Inhibidores de Anhidrasa Carbónica/química; Relación Dosis-Respuesta a Droga; Humanos; Inhibidores de la Metaloproteinasa de la Matriz/síntesis química; Inhibidores de la Metaloproteinasa de la Matriz/química; Simulación del Acoplamiento Molecular; Estructura Molecular; Peptidomiméticos/síntesis química; Peptidomiméticos/química; Prolina/síntesis química; Prolina/química; Relación Estructura-Actividad

Palabras clave

Cancer; Enzymes; Gelatinases; Hydroxamic acid; Peptidomimetics; Zinc-binding group

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Prolina / Inhibidores de Anhidrasa Carbónica / Metaloproteinasa 9 de la Matriz / Anhidrasa Carbónica II / Peptidomiméticos / Inhibidores de la Metaloproteinasa de la Matriz Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: Italia

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