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Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound.
Wellens, Sara; Dehouck, Lucie; Chandrasekaran, Vidya; Singh, Pranika; Loiola, Rodrigo Azevedo; Sevin, Emmanuel; Exner, Thomas; Jennings, Paul; Gosselet, Fabien; Culot, Maxime.
Afiliación
  • Wellens S; University of Artois, UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Faculté des sciences Jean Perrin, Rue Jean Souvraz SP18, F-62300 Lens, France.
  • Dehouck L; University of Artois, UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Faculté des sciences Jean Perrin, Rue Jean Souvraz SP18, F-62300 Lens, France.
  • Chandrasekaran V; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081HZ Amsterdam, the Netherlands.
  • Singh P; Edelweiss Connect GmbH, Technology Park Basel, Hochbergerstrasse 60C, 4057 Basel, Switzerland; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
  • Loiola RA; University of Artois, UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Faculté des sciences Jean Perrin, Rue Jean Souvraz SP18, F-62300 Lens, France.
  • Sevin E; University of Artois, UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Faculté des sciences Jean Perrin, Rue Jean Souvraz SP18, F-62300 Lens, France.
  • Exner T; Edelweiss Connect GmbH, Technology Park Basel, Hochbergerstrasse 60C, 4057 Basel, Switzerland.
  • Jennings P; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081HZ Amsterdam, the Netherlands.
  • Gosselet F; University of Artois, UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Faculté des sciences Jean Perrin, Rue Jean Souvraz SP18, F-62300 Lens, France.
  • Culot M; University of Artois, UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Faculté des sciences Jean Perrin, Rue Jean Souvraz SP18, F-62300 Lens, France. Electronic address: maxime.culot@univ-artois.fr.
Toxicol In Vitro ; 73: 105112, 2021 Jun.
Article en En | MEDLINE | ID: mdl-33631201
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Barrera Hematoencefálica / Ciclosporina / Pruebas de Toxicidad / Células Endoteliales / Células Madre Pluripotentes Inducidas / Inmunosupresores / Modelos Biológicos Tipo de estudio: Guideline / Prognostic_studies Límite: Humans Idioma: En Revista: Toxicol In Vitro Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Barrera Hematoencefálica / Ciclosporina / Pruebas de Toxicidad / Células Endoteliales / Células Madre Pluripotentes Inducidas / Inmunosupresores / Modelos Biológicos Tipo de estudio: Guideline / Prognostic_studies Límite: Humans Idioma: En Revista: Toxicol In Vitro Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Francia