Identification of Butyrylcholinesterase and Monoamine Oxidase B Targeted Ligands and their Putative Application in Alzheimer's Treatment: A Computational Strategy.

Jabir, Nasimudeen R; Rehman, Md Tabish; Tabrez, Shams; Alserihi, Raed F; AlAjmi, Mohamed F; Khan, Mohd Shahnawaz; Husain, Fohad Mabood; Ahmed, Bakrudeen Ali

Jabir, Nasimudeen R; Rehman, Md Tabish; Tabrez, Shams; Alserihi, Raed F; AlAjmi, Mohamed F; Khan, Mohd Shahnawaz; Husain, Fohad Mabood; Ahmed, Bakrudeen Ali.

Afiliación

Jabir NR; Department of Biochemistry, Centre for Research and Development, PRIST University, Vallam, Thanjavur, Tamil Nadu, India.
Rehman MT; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Tabrez S; King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Alserihi RF; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
AlAjmi MF; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Khan MS; Protein Research Chair, Department of Biochemistry, College of Sciences, King Saud University, Riyadh, Saudi Arabia.
Husain FM; Department of Food Science and Nutrition, Faculty of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.
Ahmed BA; Department of Biochemistry, Centre for Research and Development, PRIST University, Vallam, Thanjavur, Tamil Nadu, India.

Curr Pharm Des ; 27(20): 2425-2434, 2021.

Article en En | MEDLINE | ID: mdl-33634754

Asunto(s)

Enfermedad de Alzheimer; Butirilcolinesterasa; Acetilcolinesterasa/metabolismo; Anciano; Enfermedad de Alzheimer/tratamiento farmacológico; Butirilcolinesterasa/metabolismo; Inhibidores de la Colinesterasa/farmacología; Glucógeno Sintasa Quinasa 3; Humanos; Ligandos; Simulación del Acoplamiento Molecular; Monoaminooxidasa/metabolismo; Inhibidores de la Monoaminooxidasa/farmacología; Relación Estructura-Actividad

Palabras clave

Alzheimer's disease; butylrylcholinesterase; drug development; molecular docking and simulation; monoamine oxidase A; monoamine oxidase B; multi-targeted ligands.

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Butirilcolinesterasa / Enfermedad de Alzheimer Tipo de estudio: Diagnostic_studies Límite: Aged / Humans Idioma: En Revista: Curr Pharm Des Asunto de la revista: FARMACIA Año: 2021 Tipo del documento: Article País de afiliación: India

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