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Enhanced Suppression of a Protein-Protein Interaction in Cells Using Small-Molecule Covalent Inhibitors Based on an N-Acyl-N-alkyl Sulfonamide Warhead.
Ueda, Tsuyoshi; Tamura, Tomonori; Kawano, Masaharu; Shiono, Keiya; Hobor, Fruzsina; Wilson, Andrew J; Hamachi, Itaru.
Afiliación
  • Ueda T; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
  • Tamura T; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
  • Kawano M; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
  • Shiono K; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
  • Hamachi I; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
J Am Chem Soc ; 143(12): 4766-4774, 2021 03 31.
Article en En | MEDLINE | ID: mdl-33733756
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sulfonamidas / Proteína p53 Supresora de Tumor / Proteínas Proto-Oncogénicas c-mdm2 / Bibliotecas de Moléculas Pequeñas Límite: Humans Idioma: En Revista: J Am Chem Soc Año: 2021 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sulfonamidas / Proteína p53 Supresora de Tumor / Proteínas Proto-Oncogénicas c-mdm2 / Bibliotecas de Moléculas Pequeñas Límite: Humans Idioma: En Revista: J Am Chem Soc Año: 2021 Tipo del documento: Article País de afiliación: Japón