Investigation of the Click-Chemical Space for Drug Design Using ZINClick.
Methods Mol Biol
; 2266: 3-10, 2021.
Article
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| MEDLINE
| ID: mdl-33759118
ABSTRACT
This chapter provides a brief overview of the applications of ZINClick virtual library. In the last years, we have investigated the click-chemical space covered by molecules containing the triazole ring and generated a database of 1,2,3-triazoles called ZINClick, starting from literature reported alkynes and azides synthesizable in no more than three synthetic steps from commercially available products. This combinatorial database contains millions of 1,4-disubstituted 1,2,3-triazoles that are easily synthesizable. The library is regularly updated and can be freely downloaded from http//www.ZINClick.org . This virtual library is a good starting point to explore a new portion of chemical space.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Triazoles
/
Descubrimiento de Drogas
/
Química Clic
Idioma:
En
Revista:
Methods Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2021
Tipo del documento:
Article
País de afiliación:
Italia