Integration of transcriptomics and metabolomics reveals anlotinib-induced cytotoxicity in colon cancer cells.

Jia, Zhenxian; Zhang, Zhi; Tian, Qinqin; Wu, Hongjiao; Xie, Yuning; Li, Ang; Zhang, Hongmei; Yang, Zhenbang; Zhang, Xuemei

Jia, Zhenxian; Zhang, Zhi; Tian, Qinqin; Wu, Hongjiao; Xie, Yuning; Li, Ang; Zhang, Hongmei; Yang, Zhenbang; Zhang, Xuemei.

Afiliación

Jia Z; School of Public Health, North China University of Science and Technology, Tangshan 063210, China; College of Life Science, North China University of Science and Technology, Tangshan 063210, China.
Zhang Z; Affliated Tangshan Gongren Hospital, North China University of Science and Technology, Tangshan 063000, China.
Tian Q; School of Public Health, North China University of Science and Technology, Tangshan 063210, China; College of Life Science, North China University of Science and Technology, Tangshan 063210, China.
Wu H; School of Public Health, North China University of Science and Technology, Tangshan 063210, China; College of Life Science, North China University of Science and Technology, Tangshan 063210, China.
Xie Y; School of Public Health, North China University of Science and Technology, Tangshan 063210, China; College of Life Science, North China University of Science and Technology, Tangshan 063210, China.
Li A; School of Public Health, North China University of Science and Technology, Tangshan 063210, China; College of Life Science, North China University of Science and Technology, Tangshan 063210, China.
Zhang H; School of Public Health, North China University of Science and Technology, Tangshan 063210, China; College of Life Science, North China University of Science and Technology, Tangshan 063210, China.
Yang Z; School of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China.
Zhang X; School of Public Health, North China University of Science and Technology, Tangshan 063210, China; College of Life Science, North China University of Science and Technology, Tangshan 063210, China. Electronic address: jyxuemei@gmail.com.

Gene ; 786: 145625, 2021 Jun 20.

Article en En | MEDLINE | ID: mdl-33798683

Asunto(s)

Neoplasias del Colon/genética; Perfilación de la Expresión Génica/métodos; Indoles/farmacología; Metabolómica/métodos; Quinolinas/farmacología; Ácido Aspártico/metabolismo; Proteínas de Ciclo Celular/genética; Proteoglicanos Tipo Condroitín Sulfato/genética; Cromatografía Liquida; Proteínas Cromosómicas no Histona/genética; Neoplasias del Colon/química; Neoplasias del Colon/tratamiento farmacológico; ADN-Topoisomerasas de Tipo II/genética; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Redes Reguladoras de Genes; Glutamina/metabolismo; Glucógeno Fosforilasa/genética; Células HCT116; Humanos; Proteínas de Unión a Poli-ADP-Ribosa/genética; Análisis de Secuencia de ARN; Espectrometría de Masas en Tándem

Palabras clave

Anlotinib; Colon cancer; Integration; Metabolome; Transcriptome

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quinolinas / Neoplasias del Colon / Perfilación de la Expresión Génica / Metabolómica / Indoles Límite: Humans Idioma: En Revista: Gene Año: 2021 Tipo del documento: Article País de afiliación: China

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