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Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes.
Dentro, Stefan C; Leshchiner, Ignaty; Haase, Kerstin; Tarabichi, Maxime; Wintersinger, Jeff; Deshwar, Amit G; Yu, Kaixian; Rubanova, Yulia; Macintyre, Geoff; Demeulemeester, Jonas; Vázquez-García, Ignacio; Kleinheinz, Kortine; Livitz, Dimitri G; Malikic, Salem; Donmez, Nilgun; Sengupta, Subhajit; Anur, Pavana; Jolly, Clemency; Cmero, Marek; Rosebrock, Daniel; Schumacher, Steven E; Fan, Yu; Fittall, Matthew; Drews, Ruben M; Yao, Xiaotong; Watkins, Thomas B K; Lee, Juhee; Schlesner, Matthias; Zhu, Hongtu; Adams, David J; McGranahan, Nicholas; Swanton, Charles; Getz, Gad; Boutros, Paul C; Imielinski, Marcin; Beroukhim, Rameen; Sahinalp, S Cenk; Ji, Yuan; Peifer, Martin; Martincorena, Inigo; Markowetz, Florian; Mustonen, Ville; Yuan, Ke; Gerstung, Moritz; Spellman, Paul T; Wang, Wenyi; Morris, Quaid D; Wedge, David C; Van Loo, Peter.
Afiliación
  • Dentro SC; Cancer Genomics Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK; Big Data Institute, University of Oxford, Oxford OX3 7LF, UK.
  • Leshchiner I; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Haase K; Cancer Genomics Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Tarabichi M; Cancer Genomics Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • Wintersinger J; University of Toronto, Toronto, ON M5S 3E1, Canada; Vector Institute, Toronto, ON M5G 1L7, Canada.
  • Deshwar AG; University of Toronto, Toronto, ON M5S 3E1, Canada; Vector Institute, Toronto, ON M5G 1L7, Canada.
  • Yu K; The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Rubanova Y; University of Toronto, Toronto, ON M5S 3E1, Canada; Vector Institute, Toronto, ON M5G 1L7, Canada.
  • Macintyre G; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.
  • Demeulemeester J; Cancer Genomics Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Department of Human Genetics, University of Leuven, 3000 Leuven, Belgium.
  • Vázquez-García I; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK; University of Cambridge, Cambridge CB2 0QQ, UK; Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Irving Institute for Cancer Dynamics, Columbia University, New York, NY 10027, USA.
  • Kleinheinz K; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg University, 69120 Heidelberg, Germany.
  • Livitz DG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Malikic S; Cancer Data Science Laboratory, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Donmez N; Simon Fraser University, Burnaby, BC V5A 1S6, Canada; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada.
  • Sengupta S; NorthShore University HealthSystem, Evanston, IL 60201, USA.
  • Anur P; Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97231, USA.
  • Jolly C; Cancer Genomics Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Cmero M; University of Melbourne, Melbourne, VIC 3010, Australia; Walter + Eliza Hall Institute, Melbourne, VIC 3000, Australia.
  • Rosebrock D; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Schumacher SE; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Fan Y; The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Fittall M; Cancer Genomics Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Drews RM; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.
  • Yao X; Weill Cornell Medicine, New York, NY 10065, USA; New York Genome Center, New York, NY 10013, USA.
  • Watkins TBK; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
  • Lee J; University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
  • Schlesner M; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Zhu H; The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Adams DJ; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • McGranahan N; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6BT, UK; Cancer Genome Evolution Research Group, University College London Cancer Institute, London WC1E 6DD, UK.
  • Swanton C; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London WC1E 6BT, UK; Department of Medical Oncology, University College London Hospitals, London NW1 2
  • Getz G; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Massachusetts General Hospital Center for Cancer Research, Charlestown, MA 02129, USA; Massachusetts General Hospital, Department of Pathology, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02215, USA.
  • Boutros PC; University of Toronto, Toronto, ON M5S 3E1, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Imielinski M; Weill Cornell Medicine, New York, NY 10065, USA; New York Genome Center, New York, NY 10013, USA.
  • Beroukhim R; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Sahinalp SC; Cancer Data Science Laboratory, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Ji Y; NorthShore University HealthSystem, Evanston, IL 60201, USA; The University of Chicago, Chicago, IL 60637, USA.
  • Peifer M; Department of Translational Genomics, Center for Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
  • Martincorena I; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
  • Markowetz F; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.
  • Mustonen V; Organismal and Evolutionary Biology Research Programme, Department of Computer Science, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland.
  • Yuan K; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK; School of Computing Science, University of Glasgow, Glasgow G12 8RZ, UK.
  • Gerstung M; Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge CB10 1SD, UK; European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany.
  • Spellman PT; Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97231, USA.
  • Wang W; The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Morris QD; University of Toronto, Toronto, ON M5S 3E1, Canada; Vector Institute, Toronto, ON M5G 1L7, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Computational and Systems Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Wedge DC; Big Data Institute, University of Oxford, Oxford OX3 7LF, UK; Oxford NIHR Biomedical Research Centre, Oxford OX4 2PG, UK; Manchester Cancer Research Centre, University of Manchester, Manchester M20 4GJ, UK.
  • Van Loo P; Cancer Genomics Laboratory, The Francis Crick Institute, London NW1 1AT, UK. Electronic address: peter.vanloo@crick.ac.uk.
Cell ; 184(8): 2239-2254.e39, 2021 04 15.
Article en En | MEDLINE | ID: mdl-33831375
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Heterogeneidad Genética / Neoplasias Límite: Humans Idioma: En Revista: Cell Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Heterogeneidad Genética / Neoplasias Límite: Humans Idioma: En Revista: Cell Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido