Voxelotor in adolescents and adults with sickle cell disease (HOPE): long-term follow-up results of an international, randomised, double-blind, placebo-controlled, phase 3 trial.

Howard, Jo; Ataga, Kenneth I; Brown, Robert C; Achebe, Maureen; Nduba, Videlis; El-Beshlawy, Amal; Hassab, Hoda; Agodoa, Irene; Tonda, Margaret; Gray, Sarah; Lehrer-Graiwer, Joshua; Vichinsky, Elliott

Howard, Jo; Ataga, Kenneth I; Brown, Robert C; Achebe, Maureen; Nduba, Videlis; El-Beshlawy, Amal; Hassab, Hoda; Agodoa, Irene; Tonda, Margaret; Gray, Sarah; Lehrer-Graiwer, Joshua; Vichinsky, Elliott.

Afiliación

Howard J; Department of Clinical Haematology, Guy's and St Thomas' NHS Foundation Trust, London, UK. Electronic address: jo.howard@gstt.nhs.uk.
Ataga KI; University of Tennessee Health Science Center at Memphis, Memphis, TN, USA.
Brown RC; Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, and Department of Pediatrics, Emory University, Atlanta, GA, USA.
Achebe M; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nduba V; Kenya Medical Research Institute, Kisumu, Kenya.
El-Beshlawy A; Department of Pediatric Hematology, Cairo University, Cairo, Egypt.
Hassab H; Department of Pediatrics and Clinical Research Center, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Agodoa I; Global Blood Therapeutics, South San Francisco, CA, USA.
Tonda M; Global Blood Therapeutics, South San Francisco, CA, USA.
Gray S; Global Blood Therapeutics, South San Francisco, CA, USA.
Lehrer-Graiwer J; Global Blood Therapeutics, South San Francisco, CA, USA.
Vichinsky E; UCSF Benioff Children's Hospital Oakland, Oakland, CA, USA.

Lancet Haematol ; 8(5): e323-e333, 2021 May.

Article en En | MEDLINE | ID: mdl-33838113

Asunto(s)

Anemia de Células Falciformes/tratamiento farmacológico; Benzaldehídos/uso terapéutico; Pirazinas/uso terapéutico; Pirazoles/uso terapéutico; Adolescente; Adulto; Anciano; Benzaldehídos/efectos adversos; Niño; Relación Dosis-Respuesta a Droga; Método Doble Ciego; Femenino; Estudios de Seguimiento; Genotipo; Cefalea/etiología; Hemoglobina Falciforme/genética; Hemoglobina Falciforme/metabolismo; Hemoglobinas/análisis; Humanos; Masculino; Persona de Mediana Edad; Efecto Placebo; Pirazinas/efectos adversos; Pirazoles/efectos adversos; Resultado del Tratamiento; Adulto Joven

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazinas / Pirazoles / Benzaldehídos / Anemia de Células Falciformes Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Haematol Año: 2021 Tipo del documento: Article

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