Identification of gallic acid as a active ingredient of Syzygium aromaticum against tacrolimus-induced damage in renal epithelial LLC-PK1 cells and rat kidney.

Lee, Ji Hwan; Park, Musun; Jung, Kiwon; Hong, Gyeongmin; Lee, Hye Lim; Kim, Dong-Wook; Kim, Chang-Eop; Kang, Ki Sung

Lee, Ji Hwan; Park, Musun; Jung, Kiwon; Hong, Gyeongmin; Lee, Hye Lim; Kim, Dong-Wook; Kim, Chang-Eop; Kang, Ki Sung.

Afiliación

Lee JH; College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea.
Park M; Department of Physiology, College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea; Intellectual Information Team, Future Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
Jung K; Institute of Pharmaceutical Sciences, College of Pharmacy, CHA University, Sungnam 13844, Republic of Korea.
Hong G; Institute of Pharmaceutical Sciences, College of Pharmacy, CHA University, Sungnam 13844, Republic of Korea.
Lee HL; Department of Pediatrics, College of Korean Medicine, Daejeon University, Daejeon, Republic of Korea.
Kim DW; Department of Pharmaceutical Engineering, Cheongju University, Cheongju 28530, Republic of Korea.
Kim CE; Department of Physiology, College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea. Electronic address: eopchang@gachon.ac.kr.
Kang KS; College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea. Electronic address: kkang@gachon.ac.kr.

Bioorg Med Chem Lett ; 41: 128012, 2021 06 01.

Article en En | MEDLINE | ID: mdl-33838305

Asunto(s)

Ácido Gálico/farmacología; Riñón/efectos de los fármacos; Células LLC-PK1/efectos de los fármacos; Sustancias Protectoras/farmacología; Syzygium/química; Tacrolimus/antagonistas & inhibidores; Animales; Supervivencia Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Ácido Gálico/química; Masculino; Estructura Molecular; Sustancias Protectoras/química; Ratas; Ratas Sprague-Dawley; Relación Estructura-Actividad; Porcinos; Tacrolimus/farmacología

Palabras clave

FK506; Gallic acid; Nephrotoxicity; Tacrolimus

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tacrolimus / Células LLC-PK1 / Sustancias Protectoras / Syzygium / Ácido Gálico / Riñón Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article

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