Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/ß-catenin pathway.

Liu, Xiaofeng; Su, Kunqi; Sun, Xiaoyan; Jiang, Yang; Wang, Lijun; Hu, Chenyu; Zhang, Chunfeng; Lu, Min; Du, Xiaojuan; Xing, Baocai

Liu, Xiaofeng; Su, Kunqi; Sun, Xiaoyan; Jiang, Yang; Wang, Lijun; Hu, Chenyu; Zhang, Chunfeng; Lu, Min; Du, Xiaojuan; Xing, Baocai.

Afiliación

Liu X; Hepatopancreatobiliary Surgery Department I, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China. liuxiaofeng100@bjmu.edu.cn.
Su K; Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Sun X; Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Jiang Y; Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Wang L; Hepatopancreatobiliary Surgery Department I, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Hu C; Hepatopancreatobiliary Surgery Department I, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Zhang C; Department of Medical Genetics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Lu M; Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Du X; Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China. duxiaojuan100@bjmu.edu.cn.
Xing B; Hepatopancreatobiliary Surgery Department I, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China. xingbaocai88@sina.com.

J Exp Clin Cancer Res ; 40(1): 132, 2021 Apr 15.

Article en En | MEDLINE | ID: mdl-33858476

Asunto(s)

Neoplasias Colorrectales/tratamiento farmacológico; Neoplasias Colorrectales/metabolismo; Proteínas de Transporte de Membrana/metabolismo; Células Madre Neoplásicas/metabolismo; Vía de Señalización Wnt; beta Catenina/metabolismo; Animales; Línea Celular Tumoral; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/patología; Resistencia a Antineoplásicos; Femenino; Fluorouracilo/farmacología; Células HEK293; Humanos; Ratones Endogámicos BALB C; Ratones Desnudos; Células Madre Neoplásicas/patología; Oxaliplatino/farmacología; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

CRC; Cancer stem cell; Chemosensitivity; Sec62; Wnt/ß-catenin signaling; m6A modification

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas de Transporte de Membrana / Células Madre Neoplásicas / Neoplasias Colorrectales / Beta Catenina / Vía de Señalización Wnt Límite: Animals / Female / Humans Idioma: En Revista: J Exp Clin Cancer Res Año: 2021 Tipo del documento: Article País de afiliación: China

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