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Effects of a Mindfulness-Based Intervention versus Health Self-Management on Subclinical Anxiety in Older Adults with Subjective Cognitive Decline: The SCD-Well Randomized Superiority Trial.
Marchant, Natalie L; Barnhofer, Thorsten; Coueron, Roxane; Wirth, Miranka; Lutz, Antoine; Arenaza-Urquijo, Eider M; Collette, Fabienne; Poisnel, Géraldine; Demnitz-King, Harriet; Schild, Ann-Katrin; Coll-Padros, Nina; Delphin-Combe, Floriane; Whitfield, Tim; Schlosser, Marco; Gonneaud, Julie; Asselineau, Julien; Walker, Zuzana; Krolak-Salmon, Pierre; Molinuevo, José Luis; Frison, Eric; Chételat, Gael; Jessen, Frank; Klimecki, Olga M.
Afiliación
  • Marchant NL; Division of Psychiatry, University College London, London, United Kingdom.
  • Barnhofer T; Mood Disorders Centre, University of Exeter, Exeter, United Kingdom.
  • Coueron R; School of Psychology, University of Surrey, Guildford, United Kingdom.
  • Wirth M; EUCLID/F-CRIN Clinical Trials Platform, University of Bordeaux, Inserm, Bordeaux Population Health Center, Bordeaux, France.
  • Lutz A; CHU Bordeaux, Service d' Information Médicale, Bordeaux, France.
  • Arenaza-Urquijo EM; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humbold-Universität zu Berlin and Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany.
  • Collette F; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.
  • Poisnel G; Lyon Neuroscience Research Center Inserm U1028, CNRS UMR5292, Lyon 1 University, Lyon, France.
  • Demnitz-King H; Inserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Caen, France.
  • Schild AK; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
  • Coll-Padros N; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
  • Delphin-Combe F; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBER FES), Madrid, Spain.
  • Whitfield T; GIGA-CRC In Vivo Imaging, Université de Liège, National Fund for Scientific Research (F.R.S.-FNRS), Liège, Belgium.
  • Schlosser M; Inserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Caen, France.
  • Gonneaud J; Division of Psychiatry, University College London, London, United Kingdom.
  • Asselineau J; Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany.
  • Walker Z; Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic, IDIBAPS, Barcelona, Spain.
  • Krolak-Salmon P; Hospices Civils de Lyon, Institut du Vieillissement, CRC Vieillissement-Cerveau-Fragilité, Lyon, France.
  • Molinuevo JL; Division of Psychiatry, University College London, London, United Kingdom.
  • Frison E; Division of Psychiatry, University College London, London, United Kingdom.
  • Chételat G; Inserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Caen, France.
  • Jessen F; EUCLID/F-CRIN Clinical Trials Platform, University of Bordeaux, Inserm, Bordeaux Population Health Center, Bordeaux, France.
  • Klimecki OM; CHU Bordeaux, Service d' Information Médicale, Bordeaux, France.
Psychother Psychosom ; 90(5): 341-350, 2021.
Article en En | MEDLINE | ID: mdl-33873195
INTRODUCTION: Older adults experiencing subjective cognitive decline (SCD) have a heightened risk of developing dementia and frequently experience subclinical anxiety, which is itself associated with dementia risk. OBJECTIVE: To understand whether subclinical anxiety symptoms in SCD can be reduced through behavioral interventions. METHODS: SCD-Well is a randomized controlled trial designed to determine whether an 8-week mindfulness-based intervention (caring mindfulness-based approach for seniors; CMBAS) is superior to a structurally matched health self-management program (HSMP) in reducing subclinical anxiety. Participants were recruited from memory clinics at 4 European sites. The primary outcome was change in anxiety symptoms (trait subscale of the State-Trait Anxiety Inventory; trait-STAI) from pre- to postintervention. Secondary outcomes included a change in state anxiety and depression symptoms postintervention and 6 months postrandomization (follow-up). RESULTS: One hundred forty-seven participants (mean [SD] age: 72.7 [6.9] years; 64.6% women; CMBAS, n = 73; HSMP, n = 74) were included in the intention-to-treat analysis. There was no difference in trait-STAI between groups postintervention (adjusted change difference: -1.25 points; 95% CI -4.76 to 2.25) or at follow-up (adjusted change difference: -0.43 points; 95% CI -2.92 to 2.07). Trait-STAI decreased postintervention in both groups (CMBAS: -3.43 points; 95% CI -5.27 to -1.59; HSMP: -2.29 points; 95% CI -4.14 to -0.44) and reductions were maintained at follow-up. No between-group differences were observed for change in state anxiety or depression symptoms. CONCLUSIONS: A time-limited mindfulness intervention is not superior to health self-management in reducing subclinical anxiety symptoms in SCD. The sustained reduction observed across both groups suggests that subclinical anxiety symptoms in SCD are modifiable. ClinicalTrials.gov identifier: NCT03005652.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Disfunción Cognitiva / Atención Plena / Automanejo Tipo de estudio: Clinical_trials Límite: Aged / Female / Humans / Male Idioma: En Revista: Psychother Psychosom Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Disfunción Cognitiva / Atención Plena / Automanejo Tipo de estudio: Clinical_trials Límite: Aged / Female / Humans / Male Idioma: En Revista: Psychother Psychosom Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido