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Strategies for Immunomonitoring after Vaccination and during Infection.
Adam, Lucille; Rosenbaum, Pierre; Bonduelle, Olivia; Combadière, Behazine.
Afiliación
  • Adam L; Inserm, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Université, 75013 Paris, France.
  • Rosenbaum P; Inserm, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Université, 75013 Paris, France.
  • Bonduelle O; Inserm, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Université, 75013 Paris, France.
  • Combadière B; Inserm, Centre d'Immunologie et des Maladies Infectieuses, Sorbonne Université, 75013 Paris, France.
Vaccines (Basel) ; 9(4)2021 Apr 09.
Article en En | MEDLINE | ID: mdl-33918841
ABSTRACT
Immunomonitoring is the study of an individual's immune responses over the course of vaccination or infection. In the infectious context, exploring the innate and adaptive immune responses will help to investigate their contribution to viral control or toxicity. After vaccination, immunomonitoring of the correlate(s) and surrogate(s) of protection is a major asset for measuring vaccine immune efficacy. Conventional immunomonitoring methods include antibody-based technologies that are easy to use. However, promising sensitive high-throughput technologies allowed the emergence of holistic approaches. This raises the question of data integration methods and tools. These approaches allow us to increase our knowledge on immune mechanisms as well as the identification of key effectors of the immune response. However, the depiction of relevant findings requires a well-rounded consideration beforehand about the hypotheses, conception, organization and objectives of the immunomonitoring. Therefore, well-standardized and comprehensive studies fuel insight to design more efficient, rationale-based vaccines and therapeutics to fight against infectious diseases. Hence, we will illustrate this review with examples of the immunomonitoring approaches used during vaccination and the COVID-19 pandemic.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Vaccines (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Vaccines (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Francia