METTL3 enhances the stability of MALAT1 with the assistance of HuR via m6A modification and activates NF-&#954;B to promote the malignant progression of IDH-wildtype glioma.

Chang, Yu-Zhou; Chai, Rui-Chao; Pang, Bo; Chang, Xin; An, Song Yuan; Zhang, Ke-Nan; Jiang, Tao; Wang, Yong-Zhi

METTL3 enhances the stability of MALAT1 with the assistance of HuR via m6A modification and activates NF-κB to promote the malignant progression of IDH-wildtype glioma.

Chang, Yu-Zhou; Chai, Rui-Chao; Pang, Bo; Chang, Xin; An, Song Yuan; Zhang, Ke-Nan; Jiang, Tao; Wang, Yong-Zhi.

Afiliación

Chang YZ; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Chai RC; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Chinese Glioma Genome Atlas Network (CGGA), China. Electronic address: chairuichao_glia@163.com.
Pang B; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Chinese Glioma Genome Atlas Network (CGGA), China.
Chang X; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China; Chinese Glioma Genome Atlas Network (CGGA), China.
An SY; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Chinese Glioma Genome Atlas Network (CGGA), China.
Zhang KN; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Chinese Glioma Genome Atlas Network (CGGA), China.
Jiang T; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Chinese Glioma Genome Atlas Network (CGGA), China.
Wang YZ; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Chinese Glioma Genome Atlas Network (CGGA), China. Electron

Cancer Lett ; 511: 36-46, 2021 07 28.

Article en En | MEDLINE | ID: mdl-33933553

Asunto(s)

Adenosina/análogos & derivados; Neoplasias Encefálicas/metabolismo; Proteína 1 Similar a ELAV/metabolismo; Glioma/metabolismo; Metiltransferasas/metabolismo; FN-kappa B/metabolismo; ARN Largo no Codificante/metabolismo; Adenosina/metabolismo; Animales; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/patología; Carcinogénesis; Línea Celular Tumoral; Proliferación Celular/fisiología; Modelos Animales de Enfermedad; Progresión de la Enfermedad; Femenino; Glioma/genética; Glioma/patología; Xenoinjertos; Humanos; Isocitrato Deshidrogenasa/genética; Isocitrato Deshidrogenasa/metabolismo; Ratones; Ratones Endogámicos BALB C; Ratones Desnudos; Transducción de Señal

Palabras clave

Glioma; LncRNA; METTL3; NF-κB; RNA modification

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Adenosina / FN-kappa B / ARN Largo no Codificante / Proteína 1 Similar a ELAV / Glioma / Metiltransferasas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Cancer Lett Año: 2021 Tipo del documento: Article País de afiliación: China

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