Bispecific NKG2D-CD3 and NKG2D-CD16 Fusion Proteins as Novel Treatment Option in Advanced Soft Tissue Sarcomas.

Hagelstein, Ilona; Lutz, Martina S; Schmidt, Moritz; Heitmann, Jonas S; Malenke, Elke; Zhou, Yanjun; Clar, Kim L; Kopp, Hans-Georg; Jung, Gundram; Salih, Helmut R; Märklin, Melanie; Hinterleitner, Clemens

Hagelstein, Ilona; Lutz, Martina S; Schmidt, Moritz; Heitmann, Jonas S; Malenke, Elke; Zhou, Yanjun; Clar, Kim L; Kopp, Hans-Georg; Jung, Gundram; Salih, Helmut R; Märklin, Melanie; Hinterleitner, Clemens.

Afiliación

Hagelstein I; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tuebingen, Tuebingen, Germany.
Lutz MS; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, Tübingen, Germany.
Schmidt M; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tuebingen, Tuebingen, Germany.
Heitmann JS; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, Tübingen, Germany.
Malenke E; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tuebingen, Tuebingen, Germany.
Zhou Y; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, Tübingen, Germany.
Clar KL; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tuebingen, Tuebingen, Germany.
Kopp HG; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tuebingen, Tuebingen, Germany.
Jung G; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, Tübingen, Germany.
Salih HR; Department of Hematology and Oncology, Eberhard Karls University Tuebingen, Children's Hospital, Tuebingen, Germany.
Märklin M; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tuebingen, Tuebingen, Germany.
Hinterleitner C; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, Tübingen, Germany.

Front Immunol ; 12: 653081, 2021.

Article en En | MEDLINE | ID: mdl-33936075

Asunto(s)

Complejo CD3/antagonistas & inhibidores; Subfamilia K de Receptores Similares a Lectina de Células NK/genética; Receptores de IgG/antagonistas & inhibidores; Proteínas Recombinantes de Fusión/uso terapéutico; Sarcoma/tratamiento farmacológico; Adulto; Anciano; Anticuerpos Biespecíficos/genética; Anticuerpos Biespecíficos/farmacología; Complejo CD3/metabolismo; Degranulación de la Célula/efectos de los fármacos; Degranulación de la Célula/inmunología; Línea Celular Tumoral; Femenino; Proteínas Ligadas a GPI/antagonistas & inhibidores; Proteínas Ligadas a GPI/metabolismo; Humanos; Células Asesinas Naturales/efectos de los fármacos; Células Asesinas Naturales/inmunología; Células Asesinas Naturales/metabolismo; Activación de Linfocitos/efectos de los fármacos; Masculino; Persona de Mediana Edad; Subfamilia K de Receptores Similares a Lectina de Células NK/metabolismo; Cultivo Primario de Células; Dominios Proteicos/genética; Receptores de IgG/metabolismo; Proteínas Recombinantes de Fusión/genética; Proteínas Recombinantes de Fusión/aislamiento & purificación; Proteínas Recombinantes de Fusión/farmacología; Sarcoma/inmunología; Linfocitos T/efectos de los fármacos; Linfocitos T/inmunología; Linfocitos T/metabolismo; Adulto Joven

Palabras clave

CD16; CD3; NKG2DL; fusion protein; immunotherapy; mAb; sarcoma

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sarcoma / Proteínas Recombinantes de Fusión / Receptores de IgG / Complejo CD3 / Subfamilia K de Receptores Similares a Lectina de Células NK Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Alemania

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