HDAC8 promotes daunorubicin resistance of human acute myeloid leukemia cells via regulation of IL-6 and IL-8.

Wu, Jieying; Zhang, Ling; Feng, Yashu; Khadka, Bijay; Fang, Zhigang; Liu, Jiajun

Wu, Jieying; Zhang, Ling; Feng, Yashu; Khadka, Bijay; Fang, Zhigang; Liu, Jiajun.

Afiliación

Wu J; Department of Hematology and Hematology, Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Avenue, Guangzhou510630, P. R. China.
Zhang L; Department of Hematology and Hematology, Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Avenue, Guangzhou510630, P. R. China.
Feng Y; Department of Hematology and Hematology, Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Avenue, Guangzhou510630, P. R. China.
Khadka B; Department of Hematology and Hematology, Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Avenue, Guangzhou510630, P. R. China.
Fang Z; Department of Hematology and Hematology, Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Avenue, Guangzhou510630, P. R. China.
Liu J; Department of Hematology and Hematology, Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Avenue, Guangzhou510630, P. R. China.

Biol Chem ; 402(4): 461-468, 2021 03 26.

Article en En | MEDLINE | ID: mdl-33938176

Asunto(s)

Antibióticos Antineoplásicos/farmacología; Daunorrubicina/farmacología; Resistencia a Antineoplásicos/efectos de los fármacos; Histona Desacetilasas/metabolismo; Leucemia Mieloide Aguda/tratamiento farmacológico; Proteínas Represoras/metabolismo; Proliferación Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Histona Desacetilasas/genética; Humanos; Interleucina-6/antagonistas & inhibidores; Interleucina-6/genética; Interleucina-6/metabolismo; Interleucina-8/antagonistas & inhibidores; Interleucina-8/genética; Interleucina-8/metabolismo; Leucemia Mieloide Aguda/metabolismo; Leucemia Mieloide Aguda/patología; ARN Interferente Pequeño/farmacología; Proteínas Represoras/antagonistas & inhibidores; Proteínas Represoras/genética; Células Tumorales Cultivadas

Palabras clave

AML; HDAC8; IL-6; IL-8; p65; resistance

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Represoras / Leucemia Mieloide Aguda / Daunorrubicina / Resistencia a Antineoplásicos / Histona Desacetilasas / Antibióticos Antineoplásicos Límite: Humans Idioma: En Revista: Biol Chem Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google