Discovery and development of tumor glycolysis rate-limiting enzyme inhibitors.

Sun, Xueyan; Peng, Yijiao; Zhao, Jingduo; Xie, Zhizhong; Lei, Xiaoyong; Tang, Guotao

Sun, Xueyan; Peng, Yijiao; Zhao, Jingduo; Xie, Zhizhong; Lei, Xiaoyong; Tang, Guotao.

Afiliación

Sun X; Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang City, PR China.
Peng Y; Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang City, PR China.
Zhao J; Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang City, PR China.
Xie Z; Hunan Provincial Key Laboratory of tumor microenvironment responsive drug research, Hengyang City, Hunan Province, PR China.
Lei X; Hunan Provincial Key Laboratory of tumor microenvironment responsive drug research, Hengyang City, Hunan Province, PR China.
Tang G; Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang City, PR China; Hunan Provincial Key Laboratory of tumor microenvironment responsive drug research, Hengyang City, Hunan Province, PR China. E

Bioorg Chem ; 112: 104891, 2021 07.

Article en En | MEDLINE | ID: mdl-33940446

Asunto(s)

Amidas/farmacología; Proteínas Portadoras/antagonistas & inhibidores; Inhibidores Enzimáticos/farmacología; Hexoquinasa/antagonistas & inhibidores; Proteínas de la Membrana/antagonistas & inhibidores; Neoplasias/tratamiento farmacológico; Triterpenos/farmacología; Amidas/síntesis química; Amidas/química; Proteínas Portadoras/metabolismo; Desarrollo de Medicamentos; Inhibidores Enzimáticos/síntesis química; Inhibidores Enzimáticos/química; Glucólisis/efectos de los fármacos; Hexoquinasa/metabolismo; Humanos; Proteínas de la Membrana/metabolismo; Estructura Molecular; Neoplasias/metabolismo; Neoplasias/patología; Hormonas Tiroideas/metabolismo; Triterpenos/síntesis química; Triterpenos/química; Proteínas de Unión a Hormona Tiroide

Palabras clave

Glycolysis; Hexokinase; Inhibitor; Phosphofructokinase; Pyruvate kinase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Triterpenos / Proteínas Portadoras / Inhibidores Enzimáticos / Amidas / Hexoquinasa / Proteínas de la Membrana / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article

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