Introduction: Transporters, Porins, and Efflux Pumps.
Chem Rev
; 121(9): 5095-5097, 2021 05 12.
Article
en En
| MEDLINE
| ID: mdl-33975431
ABSTRACT
All living cells are surrounded by lipidic membranes that separate metabolic and macromolecular biosynthetic processes from external environments. Biological membranes vary dramatically in their composition and structures and are optimized by mega-annum of evolution to effectively carry out diverse biological functions including energy production, biosynthetic reactions, signaling, uptake of nutrients and active efflux, and others. This thematic issue of Chemical Reviews, "Transporters, Porins, and Efflux Pumps", is focused on the function of biological membranes as a permeability barrier and on the proteins that create, maintain, and bypass this barrier. Effective therapeutic interventions rely on active and passive permeation of various molecules and compounds across membranes, and our successes in development of such therapeutics are strongly affected by structural and functional insights into the assembly and function of cellular permeation barriers.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Porinas
/
Proteínas Transportadoras de Solutos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Rev
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos