Biomarkers and Fatty Fish Intake: A Randomized Controlled Trial in Norwegian Preschool Children.
J Nutr
; 151(8): 2134-2141, 2021 08 07.
Article
en En
| MEDLINE
| ID: mdl-33978160
ABSTRACT
BACKGROUND:
Biomarkers such as omega-3 (n-3) PUFAs, urinary iodine concentration (UIC), 1-methylhistidine (1-MH), and trimethylamine N-oxide (TMAO) have been associated with fish intake in observational studies, but data from children in randomized controlled trials are limited.OBJECTIVES:
The objective of this exploratory analysis was to investigate the effects of fatty fish intake compared with meat intake on various biomarkers in preschool children.METHODS:
We randomly allocated (11) 232 children, aged 4 to 6 y, from 13 kindergartens. The children received lunch meals of either fatty fish (herring/mackerel) or meat (chicken/lamb/beef) 3 times a week for 16 wk. We analyzed 86 biomarkers in plasma (n = 207), serum (n = 195), RBCs (n = 211), urine (n = 200), and hair samples (n = 210). We measured the effects of the intervention on the normalized biomarker concentrations in linear mixed-effect regression models taking the clustering within the kindergartens into account. The results are presented as standardized effect sizes.RESULTS:
We found significant effects of the intervention on the following biomarkers RBC EPA (205n-3), 0.61 (95% CI 0.36, 0.86); DHA (226n-3), 0.43 (95% CI 0.21, 0.66); total n-3 PUFAs, 0.41 (95% CI 0.20, 0.64); n-3/n-6 ratio, 0.48 (95% CI 0.24, 0.71); adrenic acid (224n-6, -0.65 (95% CI -0.91, -0.40), arachidonic acid (204n-6), -0.54 (95% CI -0.79, -0.28); total n-6 PUFAs, -0.31 (95% CI -0.56, -0.06); UIC, 0.32 (95% CI 0.052, 0.59); hair mercury, 0.83 (95% CI 0.05, 1.05); and plasma 1-MH, -0.35 (95% CI -0.61, -0.094).CONCLUSIONS:
Of the 86 biomarkers, the strongest effect of fatty fish intake was on n-3 PUFAs, UIC, hair mercury, and plasma 1-MH. We observed no or limited effects on biomarkers related to micronutrient status, inflammation, or essential amino acid, choline oxidation, and tryptophan pathways.The trial was registered at clinicaltrials.gov (NCT02331667).Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ácidos Grasos Omega-3
Tipo de estudio:
Clinical_trials
/
Observational_studies
Límite:
Animals
/
Child, preschool
/
Humans
Idioma:
En
Revista:
J Nutr
Año:
2021
Tipo del documento:
Article
País de afiliación:
Noruega