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Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.
Grand, Darren Le; Gosling, Martin; Baettig, Urs; Bahra, Parmjit; Bala, Kamlesh; Brocklehurst, Cara; Budd, Emma; Butler, Rebecca; Cheung, Atwood K; Choudhury, Hedaythul; Collingwood, Stephen P; Cox, Brian; Danahay, Henry; Edwards, Lee; Everatt, Brian; Glaenzel, Ulrike; Glotin, Anne-Lise; Groot-Kormelink, Paul; Hall, Edward; Hatto, Julia; Howsham, Catherine; Hughes, Glyn; King, Anna; Koehler, Julia; Kulkarni, Swarupa; Lightfoot, Megan; Nicholls, Ian; Page, Christopher; Pergl-Wilson, Giles; Popa, Mariana Oana; Robinson, Richard; Rowlands, David; Sharp, Tom; Spendiff, Matthew; Stanley, Emily; Steward, Oliver; Taylor, Roger J; Tranter, Pamela; Wagner, Trixie; Watson, Hazel; Williams, Gareth; Wright, Penny; Young, Alice; Sandham, David A.
Afiliación
  • Grand DL; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Gosling M; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Baettig U; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Bahra P; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Bala K; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Brocklehurst C; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, CH 4002, Switzerland.
  • Budd E; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Butler R; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Cheung AK; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States.
  • Choudhury H; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Collingwood SP; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Cox B; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Danahay H; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Edwards L; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Everatt B; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Glaenzel U; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, CH 4002, Switzerland.
  • Glotin AL; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Groot-Kormelink P; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, CH 4002, Switzerland.
  • Hall E; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States.
  • Hatto J; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Howsham C; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Hughes G; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • King A; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Koehler J; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, CH 4002, Switzerland.
  • Kulkarni S; Novartis Institutes for Biomedical Research, East Hanover, New Jersey 07936, United States.
  • Lightfoot M; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Nicholls I; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, CH 4002, Switzerland.
  • Page C; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Pergl-Wilson G; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Popa MO; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Robinson R; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States.
  • Rowlands D; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States.
  • Sharp T; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Spendiff M; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Stanley E; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Steward O; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Taylor RJ; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Tranter P; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Wagner T; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, CH 4002, Switzerland.
  • Watson H; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Williams G; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, CH 4002, Switzerland.
  • Wright P; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Young A; Novartis Institutes for Biomedical Research, Horsham Research Center, Wimblehurst Road, Horsham RH12 5AB, U.K.
  • Sandham DA; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States.
J Med Chem ; 64(11): 7241-7260, 2021 06 10.
Article en En | MEDLINE | ID: mdl-34028270
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulador de Conductancia de Transmembrana de Fibrosis Quística / Aminopiridinas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulador de Conductancia de Transmembrana de Fibrosis Quística / Aminopiridinas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido